Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Nanomedicine. 2010 Apr;6(2):245-56. doi: 10.1016/j.nano.2009.07.003. Epub 2009 Aug 20.
Carbon nanotubes (CNTs) have recently emerged as a new option for possible use in methodologies of cancer treatment, bioengineering, and gene therapy. This review analyzes the potential, through possible toxicologic implications, of CNTs in nanomedicine. Generally, proven success in other fields may not translate to the use of CNTs in medicine for reasons including inconsistent data on cytotoxicity and limited control over functionalized-CNT behavior, both of which restrict predictability. Additionally, the lack of a centralized toxicity database limits comparison between research results. To better understand these problems, we seek insight from currently published toxicity studies, with data suggesting postexposure regeneration, resistance, and mechanisms of injury in cells, due to CNTs.
Carbon nanotubes (CNTs) have recently emerged as a new option for cancer treatment, bioengineering, and gene therapy. Inconsistent data on cytotoxicity and limited control over functionalized-CNT behavior currently restrict predictability of such applications.
碳纳米管（CNTs）最近作为癌症治疗、生物工程和基因治疗方法的可能选择而出现。这篇综述分析了 CNTs 在纳米医学中可能存在的毒性问题。通常，其他领域的成功经验不一定适用于 CNTs 在医学中的应用，原因包括细胞毒性方面的数据不一致，以及对功能化 CNT 行为的控制有限，这两者都限制了可预测性。此外，缺乏集中的毒性数据库限制了研究结果之间的比较。为了更好地理解这些问题，我们从目前已发表的毒性研究中寻求见解，数据表明 CNTs 会导致细胞暴露后的再生、耐药性和损伤机制。
碳纳米管（CNTs）最近作为癌症治疗、生物工程和基因治疗的新选择出现。细胞毒性方面的数据不一致，以及对功能化 CNT 行为的控制有限，目前限制了此类应用的可预测性。
