Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA.
Alzheimers Dement. 2010 May;6(3):247-56. doi: 10.1016/j.jalz.2010.03.001.
The Alzheimer's Diseases Neuroimaging Initiative project has brought together geographically distributed investigators, each collecting data on the progression of Alzheimer's disease. The quantity and diversity of the imaging, clinical, cognitive, biochemical, and genetic data acquired and generated throughout the study necessitated sophisticated informatics systems to organize, manage, and disseminate data and results. We describe, here, a successful and comprehensive system that provides powerful mechanisms for processing, integrating, and disseminating these data not only to support the research needs of the investigators who make up the Alzheimer's Diseases Neuroimaging Initiative cores, but also to provide widespread data access to the greater scientific community for the study of Alzheimer's Disease.
阿尔茨海默病神经影像学倡议项目汇集了分布在不同地区的研究人员,他们各自收集阿尔茨海默病进展的数据。在整个研究过程中,获取和生成的影像学、临床、认知、生化和遗传数据的数量和多样性需要复杂的信息学系统来组织、管理和传播数据和结果。在这里,我们描述了一个成功的、全面的系统,它提供了强大的机制来处理、整合和传播这些数据,不仅支持组成阿尔茨海默病神经影像学倡议核心的研究人员的研究需求,而且为更广泛的科学界提供了广泛的数据访问,以研究阿尔茨海默病。