IRCCS Fatebenefratelli, The National Centre for Research and Care of Alzheimer's Disease, Brescia, Italy.
Alzheimers Dement. 2010 May;6(3):280-5. doi: 10.1016/j.jalz.2010.03.005.
The North American Alzheimer's Disease Neuroimaging Initiative (ADNI) was originally conceived as a study to develop markers of disease progression, but has also become a strong technological platform for the multi-centric collection of clinical data and imaging and biological markers. Because the ADNI platform was first imported in Europe, thanks to the pilot European ADNI, several ADNI-related initiatives have flourished, funded by the European Commission's 7th Framework Programme, national governments, and the Alzheimer's Association aimed at: (i) collecting fresh data ADNI style (FP7 AddNeuroMed, Innovative Medicine Initiative Pharma-Cog/European ADNI, Swedish ADNI, and Italian ADNI); (ii) developing standard operational procedures for the collection of markers (International Harmonization of CSF Abeta42 and tau, and European Alzheimer's Disease Consortium-ADNI Harmonization of Hippocampal Volumetry); and (iii) developing infrastructures for the treatment of ADNI data (FP7 neuGRID and outGRID, and the French Centre pour l'Acquisition et le Traitement de l'Image). Although this fragmented scenario is not surprising given the structure of scientific funding in Europe, opportunities are being developed for high order networking and harmonization at the continental level (Joint Programming for Neurodegenerative Diseases).
北美阿尔茨海默病神经影像学倡议（ADNI）最初被设想为一项旨在开发疾病进展标志物的研究，但它也已成为一个强大的技术平台，用于多中心收集临床数据、影像和生物标志物。由于 ADNI 平台最初是在欧洲引入的，多亏了试点性的欧洲 ADNI，几个与 ADNI 相关的倡议如雨后春笋般涌现，这些倡议由欧盟委员会第 7 框架计划、各国政府以及阿尔茨海默病协会资助，旨在：（i）采用 ADNI 式的方式收集新数据（FP7 AddNeuroMed、创新性药物倡议 Pharma-Cog/欧洲 ADNI、瑞典 ADNI 和意大利 ADNI）；（ii）制定用于收集标志物的标准操作规程（国际 CSF Abeta42 和 tau 标准化、欧洲阿尔茨海默病协会-ADNI 海马体积标准化）；（iii）开发 ADNI 数据处理基础设施（FP7 neuGRID 和 outGRID 以及法国图像获取与处理中心）。虽然考虑到欧洲科学资助的结构，这种分散的情况并不令人惊讶，但正在为欧洲大陆层面的高级别网络和协调开发机会（神经退行性疾病联合规划）。
