Julius-Maximilians-Universität Würzburg, Institut für Molekulare Infektionsbiologie, Josef-Schneider-Str. 2/Bau D15, 97080 Würzburg, Germany.
Int J Med Microbiol. 2010 Aug;300(6):363-6. doi: 10.1016/j.ijmm.2010.04.010. Epub 2010 May 7.
Bacterial pathogens with the ability to cause persistent infection have different strategies to withstand the induction of host immune responses and to successfully establish long-term colonization. In case of asymptomatic bacteriuria and other persistent infections, prolonged growth in the host is accompanied with genomic alterations that result in e.g., bacterial attenuation thus contributing to bacterial adaptation to their host niche and a reduced activation of host immune responses. The accumulating amount of information regarding bacterial adaptation during persistent infection helps to increase our understanding of driving forces of bacterial adaptation in vivo as well as of factors that contribute to symptomatic infection.
具有引起持续性感染能力的细菌病原体具有不同的策略来抵抗宿主免疫反应的诱导，并成功建立长期定植。在无症状菌尿和其他持续性感染的情况下，细菌在宿主体内的长时间生长伴随着基因组改变，导致细菌衰减，从而有助于细菌适应其宿主小生境，并减少宿主免疫反应的激活。关于持续性感染期间细菌适应的积累信息有助于提高我们对细菌在体内适应的驱动力以及导致症状性感染的因素的理解。
