Wonglapsuwan Monwadee, Pahumunto Nuntiya, Teanpaisan Rawee, Surachat Komwit
Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Research Center of Excellence for Oral Health, Faculty of Dentistry, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Heliyon. 2024 Apr 14;10(8):e29499. doi: 10.1016/j.heliyon.2024.e29499. eCollection 2024 Apr 30.
is a group of probiotic strains that have gained popularity for their potential health benefits such as promoting digestive health, boosting the immune system, improving lactose digestion, preventing and treating antibiotic-associated diarrhea, reducing the severity and duration of certain infections, and preventing the formation of dental plaque. In particular, strains SD4 and SD11 have promising human and animal health applications due to their ability to inhibit the growth of harmful pathogens. This study presents an genomic analysis of strains SD4 and SD11. We analyzed draft genomes and conducted comparative genome analyses against several other probiotic strains, aiming to gain insights into the genomes of the two strains and to compare them to related strains isolated from other sources. We also aimed to clarify the functional mechanisms and adaptation of these strains to specific environments. Comprehensive insights into the genomes of SD4 and SD11 could enhance our understanding of their capacity to colonize, adapt, and exhibit probiotic properties after administration. This study holds significance in advancing our understanding of the potential health benefits associated with these strains and in elucidating the underlying mechanisms responsible for their effectiveness in humans and animals.
是一组益生菌菌株，因其潜在的健康益处而受到欢迎，例如促进消化健康、增强免疫系统、改善乳糖消化、预防和治疗抗生素相关性腹泻、减轻某些感染的严重程度和持续时间以及预防牙菌斑形成。特别是，SD4和SD11菌株因其抑制有害病原体生长的能力而在人类和动物健康应用方面具有前景。本研究对SD4和SD11菌株进行了基因组分析。我们分析了草图基因组，并与其他几种益生菌菌株进行了比较基因组分析，旨在深入了解这两种菌株的基因组，并将它们与从其他来源分离的相关菌株进行比较。我们还旨在阐明这些菌株的功能机制以及它们对特定环境的适应性。对SD4和SD11基因组的全面深入了解可以增强我们对它们在给药后定殖、适应和表现出益生菌特性能力的理解。这项研究对于推进我们对与这些菌株相关的潜在健康益处的理解以及阐明它们在人类和动物中有效性的潜在机制具有重要意义。
