Notch 对骨骼成肌的调控作用。
Regulation of skeletal myogenesis by Notch.
机构信息
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6145, USA.
出版信息
Exp Cell Res. 2010 Nov 1;316(18):3028-33. doi: 10.1016/j.yexcr.2010.05.002. Epub 2010 May 7.
Abstract
Notch signaling has emerged as a key player in skeletal muscle development and regeneration. Simply stated, Notch signaling inhibits differentiation. Accordingly, fine-tuning the pathway is essential for proper muscle homeostasis. This review will address various aspects of Notch signaling, including our current views of the core pathway, its effects in muscle, its interactions with other signaling pathways, and its relationship with ageing.
摘要
Notch 信号通路在骨骼肌发育和再生中起着关键作用。简单地说，Notch 信号通路抑制分化。因此，对该途径进行精细调控对于维持肌肉内环境稳定至关重要。本文将讨论 Notch 信号通路的各个方面，包括我们目前对核心通路的认识、它在肌肉中的作用、它与其他信号通路的相互作用以及它与衰老的关系。
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