McAuley School of Nursing, University of Detroit Mercy, MI 48221, USA.
Biol Res Nurs. 2010 Jul;12(1):54-61. doi: 10.1177/1099800410365368. Epub 2010 May 7.
To explore the influence of reproductive aging, body mass index (BMI), and the menstrual cycle on adiponectin (AD) and leptin concentrations.
Cross-sectional comparison in age- and BMI-matched nonobese volunteers with regular cycles (CO, n = 19) or in early postmenopause (EPM, n = 19), aged 40-52 years, and a young cycling group (CY, n = 21), aged 20-30 years.
Sex steroids, fasting AD, leptin, insulin, glucose, AD/leptin (A/L) ratio, and insulin resistance (IR) by homeostasis model assessment (HOMA-IR). In ovulatory women, AD, estradiol (E(2)), and progesterone were assessed weekly across the same menstrual cycle.
Insulin, glucose, HOMA-IR, A/L ratio, and leptin values were similar across the three study groups. AD differed, with the highest concentrations in the EPM group (CY: 13.0 +/- 0.9 microg/ml vs. CO: 14.0 +/- 1.1 microg/ml vs. EPM: 17.7 +/- 1.5 microg/ml; p = .05). Values among cycling women were similar. When the cycling groups were combined into a premenopausal (PRE) group and compared to EPM women by BMI (> or <or=25 kg/m(2)), leptin concentrations were higher and A/L ratios lower in PRE and EPM overweight (OW) subgroups versus normal-weight (NW) subgroups. AD was lower in OW, cycling women and higher in the NW EPM subgroup compared to NW PRE women. In cycling women, AD did not vary across the menstrual cycle.
Nonobese, midlife women experience minimal adverse effects from reproductive aging on insulin sensitivity and adipokine secretion. The menstrual cycle is not a key mediator of AD. Early menopause has differential, BMI-dependent effects on adipokine secretion.
探讨生殖衰老、体重指数（BMI）和月经周期对脂联素（AD）和瘦素浓度的影响。
在年龄和 BMI 匹配的非肥胖、月经周期正常的志愿者（CO 组，n=19）或早绝经（EPM 组，n=19）、年龄 40-52 岁，以及年轻的月经周期正常的志愿者（CY 组，n=21）中进行横断面比较。
性激素、空腹 AD、瘦素、胰岛素、血糖、AD/瘦素（A/L）比值和稳态模型评估的胰岛素抵抗（HOMA-IR）。在排卵女性中，在同一月经周期中每周评估 AD、雌二醇（E2）和孕酮。
胰岛素、血糖、HOMA-IR、A/L 比值和瘦素值在三组研究对象中相似。AD 不同，EPM 组浓度最高（CY 组：13.0±0.9μg/ml 比 CO 组：14.0±1.1μg/ml 比 EPM 组：17.7±1.5μg/ml；p=0.05）。月经周期正常的女性中数值相似。当将月经周期正常的女性组合为一个绝经前（PRE）组，并根据 BMI（>或<或=25kg/m2）与 EPM 女性进行比较时，PRE 和 EPM 超重（OW）亚组的瘦素浓度较高，A/L 比值较低，而 NW 亚组则相反。OW 组的 AD 较低，CY 组和 NW 组的 EPM 亚组的 AD 较高，与 NW PRE 女性相比。在月经周期正常的女性中，AD 并未在月经周期中发生变化。
非肥胖的中年女性经历生殖衰老对胰岛素敏感性和脂肪细胞因子分泌的影响很小。月经周期并不是 AD 的关键调节因素。早绝经对脂肪细胞因子分泌有不同的、BMI 依赖性的影响。
