绝经后妇女的血浆催乳素水平与新发高血压的风险。
Plasma prolactin level and risk of incident hypertension in postmenopausal women.
机构信息
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
出版信息
J Hypertens. 2010 Jul;28(7):1400-5. doi: 10.1097/HJH.0b013e328339f254.
BACKGROUND
Laboratory and cross-sectional human studies suggest a potential role for prolactin in the pathogenesis of hypertension; however, the prospective association between prolactin and hypertension has not been previously reported.
METHODS
We prospectively examined the association between daytime plasma prolactin levels and the risk of incident hypertension among 874 postmenopausal women who were participants of the Nurses' Health Study. Cox proportional hazards regression models were used to adjust for potential confounders.
RESULTS
We identified 183 incident cases of hypertension during 8 years of follow-up. After adjusting for potential confounders, the relative risk of hypertension for a 1-standard deviation higher plasma prolactin was 1.31 (95% confidence interval 1.05-1.62). Compared with women with plasma prolactin levels of 8.0 ng/ml or below, the multivariable relative risk of incident hypertension for those with prolactin levels above 8.0 ng/ml was 1.34 (95% confidence interval 0.90-1.99).
CONCLUSION
A higher daytime plasma prolactin level is independently associated with an increased risk of incident hypertension among postmenopausal women.
背景
实验室和横断面人体研究表明，催乳素在高血压发病机制中可能起作用；然而，催乳素与高血压之间的前瞻性关联尚未被报道过。
方法
我们前瞻性地研究了白天血浆催乳素水平与护士健康研究中 874 名绝经后妇女中高血压发病风险之间的关联。Cox 比例风险回归模型用于调整潜在的混杂因素。
结果
我们在 8 年的随访中发现了 183 例高血压事件。在调整了潜在的混杂因素后，血浆催乳素每升高 1 个标准差，高血压的相对风险为 1.31（95%置信区间为 1.05-1.62）。与催乳素水平在 8.0ng/ml 或以下的女性相比，催乳素水平高于 8.0ng/ml 的女性发生高血压的多变量相对风险为 1.34（95%置信区间为 0.90-1.99）。
结论
白天较高的血浆催乳素水平与绝经后妇女中高血压的发病风险增加独立相关。
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