Children's Hospital, University Medical Center, Erlangen, Germany.
J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):103-5. doi: 10.1097/MPG.0b013e3181cd26f9.
: Development of the mucosal immune system is essential for controlling antigenic response. External factors are known to influence the immune system, such as breast-feeding or the mode of delivery. The aim of the present study was to investigate maturation of the enteric immune system.
: In stool samples of 59 preterm and term-born infants we measured the concentration of human beta-defensin 2 (HBD 2), an endogenous antimicrobial peptide, and tumor necrosis factor-alpha (TNF-alpha), a cytokine playing a central role in mucosal inflammation, by enzyme-linked immunosorbent assay.
: Mode of delivery as well as nutrition (breast-feeding or formula) had no influence on the fecal concentration of HBD-2 or TNF-alpha, but there was a significant increase in the concentration of HBD-2 in correlation with gestational age. TNF-alpha showed no change in concentration.
: Low fecal HBD-2 may be a risk factor in preterm infants to develop neonatal enteric disease, such as necrotizing enterocolitis.
黏膜免疫系统的发育对于控制抗原反应至关重要。已知外部因素会影响免疫系统，例如母乳喂养或分娩方式。本研究旨在研究肠内免疫系统的成熟度。
在 59 名早产儿和足月产儿的粪便样本中，我们通过酶联免疫吸附试验测量了人β防御素 2（HBD 2），一种内源性抗菌肽，和肿瘤坏死因子-α（TNF-α）的浓度，后者在黏膜炎症中起核心作用。
分娩方式以及营养（母乳喂养或配方奶）对 HBD-2 或 TNF-α的粪便浓度均无影响，但 HBD-2 的浓度与胎龄呈显著正相关。TNF-α的浓度没有变化。
低粪便 HBD-2 可能是早产儿发生新生儿肠病（如坏死性小肠结肠炎）的危险因素。
