调节肠道上皮更新、分化、迁移和细胞死亡的炎症信号：对坏死性小肠结肠炎的影响。
Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis.
作者信息
Kandasamy Jegen, Huda Shehzad, Ambalavanan Namasivayam, Jilling Tamas
机构信息
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Alabama at Birmingham, USA.
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Alabama at Birmingham, USA.
出版信息
Pathophysiology. 2014 Feb;21(1):67-80. doi: 10.1016/j.pathophys.2014.01.001. Epub 2014 Feb 16.
Abstract
Necrotizing enterocolitis is a disease entity with multiple proposed pathways of pathogenesis. Various combinations of these risk factors, perhaps based on genetic predisposition, possibly lead to the mucosal and epithelial injury that is the hallmark of NEC. Intestinal epithelial integrity is controlled by a tightly regulated balance between proliferation and differentiation of epithelium from intestinal epithelial stem cells and cellular loss by apoptosis. various signaling pathways play a key role in creating and maintaining this balance. The aim of this review article is to outline intestinal epithelial barrier development and structure and the impact of these inflammatory signaling and regulatory pathways as they pertain to the pathogenesis of NEC.
摘要
坏死性小肠结肠炎是一种具有多种发病机制途径的疾病实体。这些风险因素的各种组合，可能基于遗传易感性，可能导致黏膜和上皮损伤，这是坏死性小肠结肠炎的标志。肠道上皮完整性由肠道上皮干细胞上皮细胞增殖与分化以及细胞凋亡导致的细胞损失之间严格调控的平衡所控制。各种信号通路在建立和维持这种平衡中起关键作用。这篇综述文章的目的是概述肠道上皮屏障的发育和结构，以及这些炎症信号和调节通路在坏死性小肠结肠炎发病机制中的影响。
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