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盐酸氨基葡萄糖功能化四苯乙烯：基于聚集诱导发光的碱性磷酸酶新型荧光探针

Glucosamine hydrochloride functionalized tetraphenylethylene: a novel fluorescent probe for alkaline phosphatase based on the aggregation-induced emission.

机构信息

National Center for Nanoscience and Technology, Beijing 100190, China.

出版信息

Chem Commun (Camb). 2010 Jun 21;46(23):4067-9. doi: 10.1039/c002894k. Epub 2010 May 10.

DOI:10.1039/c002894k
PMID:20454747
Abstract

Grafting of glucosamine hydrochloride moieties to tetraphenylethylene (TPE) motif furnished a novel cationic water-soluble tetraphenylethylene derivative (GH-TPE). With aggregation-induced emission properties, GH-TPE was used for fluorometric detection to alkaline phosphatase through enzyme-triggered de-aggregation of the ensemble of GH-TPE and substrate.

摘要

将盐酸氨基葡萄糖部分接枝到四苯乙烯（TPE）基上，得到了一种新型的阳离子水溶性四苯乙烯衍生物（GH-TPE）。GH-TPE 具有聚集诱导发射性质，可通过酶触发 GH-TPE 与底物的聚集物解聚，用于碱性磷酸酶的荧光检测。

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