Department of Kinesiology, The University of Texas at El Paso, 1101 N Campbell St, El Paso, TX 79902, USA.
Acta Diabetol. 2012 Dec;49 Suppl 1(0 1):S41-9. doi: 10.1007/s00592-010-0192-6. Epub 2010 May 8.
The purpose of this study was to examine insulin resistance, markers of the metabolic syndrome, cardiovascular disease (CVD) risk, and serum adiponectin concentrations in pre-menopausal Hispanic and non-Hispanic White (NHW) women. This cross-sectional study examined 119 pre-menopausal women (76 Hispanic, 45 NHW) for markers of the metabolic syndrome (ATP III criteria), level of insulin resistance (HOMA-IR), CVD risk factors, and serum total adiponectin concentrations. Relationships between variables were assessed using Student's t-tests, Pearson's and Spearman's Rho correlations, and stepwise multiple regression analysis. Hispanic women had significantly lower adiponectin concentrations than NHW women, even after controlling for body fat (%) (P < 0.01). Number of markers of the metabolic syndrome was inversely related to total adiponectin concentration for all women combined and for NHW women (P ≤ 0.04), but not for Hispanic women. Insulin resistance was inversely related to adiponectin for all women and for NHW women (P < 0.01), but not significantly associated in Hispanic women. Adiponectin concentration was not significantly associated with number of CVD risk factors for these women. While adiponectin was associated with markers of metabolic syndrome and insulin resistance for all women of this study and despite lower adiponectin concentrations for Hispanic women than NHW women, the role of adiponectin to these conditions among Hispanics remains unclear. There was no significant association between adiponectin and CVD risk for these women. Future research should focus on understanding mechanisms for up-regulating adiponectin secretion and if ethnicity affects adiponectin gene expression and secretion given the beneficial effects derived from elevated adiponectin levels.
本研究旨在探讨绝经前西班牙裔和非西班牙裔白人（NHW）女性的胰岛素抵抗、代谢综合征标志物、心血管疾病（CVD）风险和血清脂联素浓度。本横断面研究检查了 119 名绝经前女性（76 名西班牙裔，45 名 NHW）的代谢综合征标志物（ATP III 标准）、胰岛素抵抗水平（HOMA-IR）、CVD 风险因素和血清总脂联素浓度。使用学生 t 检验、Pearson 和 Spearman Rho 相关分析以及逐步多元回归分析评估变量之间的关系。尽管控制了体脂（%）（P < 0.01），但西班牙裔女性的脂联素浓度明显低于 NHW 女性。代谢综合征标志物的数量与所有女性和 NHW 女性的总脂联素浓度呈负相关（P ≤ 0.04），但与西班牙裔女性无关。胰岛素抵抗与所有女性和 NHW 女性的脂联素呈负相关（P < 0.01），但在西班牙裔女性中无显著相关性。脂联素浓度与这些女性的 CVD 风险因素数量无显著相关性。尽管脂联素与所有女性的代谢综合征标志物和胰岛素抵抗相关，并且西班牙裔女性的脂联素浓度低于 NHW 女性，但脂联素在西班牙裔人群中对这些疾病的作用仍不清楚。脂联素与这些女性的 CVD 风险无显著相关性。未来的研究应集中于了解上调脂联素分泌的机制，以及种族是否会影响脂联素基因表达和分泌，因为升高的脂联素水平具有有益的作用。
