• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脂联素和性激素与未经药物治疗的受试者代谢综合征各组分的相关性：来自 Brisighella 心脏研究的数据。

Adipokines and sexual hormones associated with the components of the metabolic syndrome in pharmacologically untreated subjects: data from the brisighella heart study.

机构信息

Department of Internal Medicine, Aging and Kidney Disease Department, University of Bologna, 40138 Bologna, Italy.

出版信息

Int J Endocrinol. 2011;2011:724816. doi: 10.1155/2011/724816. Epub 2011 Nov 9.

DOI:10.1155/2011/724816
PMID:22114592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3216320/
Abstract

We evaluated the association of the sex hormone pattern and the serum level of the main adipokines to metabolic syndrome (MS) and its components in 199 pharmacologically untreated subjects. Men and women included in the age-class subgroups were matched for body mass index, waist circumference, blood pressure, heart rate, fasting plasma glucose, and plasma lipids. Men without MS had significantly lower leptin/adiponectin ratio than men with MS. Women without MS had lower leptin and leptin/adiponectin ratio than women with MS but had significantly higher adiponectin, estrone, and dehydroepiandrosterone levels. In men, the leptin/adiponectin ratio is the main factor associated to MS diagnosis (OR: 3.36, 95% CI 1.40-8.08), while in women adiponectin alone appears to be a protective factor (OR: 0.87, 95% CI 0.79-0.95). In conclusion, in a sample of pharmacologically untreated subjects, leptin/adiponectin ratio seems to be the factor more strongly associated to MS and its components.

摘要

我们评估了 199 例未经药物治疗的受试者的性激素模式和主要脂肪因子的血清水平与代谢综合征（MS）及其成分之间的关联。纳入年龄亚组的男性和女性按体重指数、腰围、血压、心率、空腹血糖和血浆脂质进行匹配。无 MS 的男性的瘦素/脂联素比值明显低于有 MS 的男性。无 MS 的女性的瘦素和瘦素/脂联素比值低于有 MS 的女性，但脂联素、雌酮和脱氢表雄酮水平明显更高。在男性中，瘦素/脂联素比值是与 MS 诊断相关的主要因素（OR：3.36，95%CI 1.40-8.08），而在女性中，脂联素似乎是一个保护因素（OR：0.87，95%CI 0.79-0.95）。总之，在一组未经药物治疗的受试者中，瘦素/脂联素比值似乎与 MS 及其成分的关联更密切。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6e9/3216320/4eae1e99cad5/IJE2011-724816.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6e9/3216320/4eae1e99cad5/IJE2011-724816.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6e9/3216320/4eae1e99cad5/IJE2011-724816.001.jpg

相似文献

1
Adipokines and sexual hormones associated with the components of the metabolic syndrome in pharmacologically untreated subjects: data from the brisighella heart study.脂联素和性激素与未经药物治疗的受试者代谢综合征各组分的相关性：来自 Brisighella 心脏研究的数据。
Int J Endocrinol. 2011;2011:724816. doi: 10.1155/2011/724816. Epub 2011 Nov 9.
2
Metabolic syndrome, adipokines and hormonal factors in pharmacologically untreated adult elderly subjects from the Brisighella Heart Study historical cohort.布里斯吉尔拉心脏研究历史队列中未经药物治疗的成年老年患者的代谢综合征、脂肪因子和激素因素。
Obes Facts. 2012;5(3):319-26. doi: 10.1159/000339575. Epub 2012 Jun 12.
3
Sex hormones and adipokines in healthy pre-menopausal, post-menopausal and elderly women, and in age-matched men: data from the Brisighella Heart study.健康绝经前、绝经后和老年女性以及年龄匹配男性的性激素和脂肪细胞因子：来自 Brisighella 心脏研究的数据。
J Endocrinol Invest. 2011 Jul-Aug;34(7):e158-62. doi: 10.3275/7407. Epub 2010 Dec 15.
4
Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia.瘦素/脂联素比值可作为精神分裂症患者代谢综合征的潜在生物标志物。
Psychoneuroendocrinology. 2018 Jun;92:34-40. doi: 10.1016/j.psyneuen.2018.03.021. Epub 2018 Mar 29.
5
[Relationship between metabolic syndrome and adipokines on diabetes among high-risk populations].[高危人群中代谢综合征及脂肪因子与糖尿病的关系]
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Apr;33(4):418-22.
6
Leptin/adiponectin ratio in patients with coronary heart disease: comparing subjects with and without metabolic syndrome.冠心病患者瘦素/脂联素比值：比较合并和不合并代谢综合征的患者。
Ann Clin Biochem. 2011 Jul;48(Pt 4):327-31. doi: 10.1258/acb.2011.010199. Epub 2011 Apr 18.
7
Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population.撒哈拉以南非洲人群中血清瘦素和脂联素与肥胖、血脂及胰岛素抵抗人体测量指标的关联
Lipids Health Dis. 2016 May 17;15:96. doi: 10.1186/s12944-016-0264-x.
8
Association of adipokines with metabolic disorders in patients with schizophrenia: Results of comparative study with mental healthy cohort.精神分裂症患者中脂肪因子与代谢紊乱的关联：与心理健康队列的比较研究结果
Diabetes Metab Syndr. 2015 Jul-Sep;9(3):163-7. doi: 10.1016/j.dsx.2015.04.009. Epub 2015 Apr 24.
9
Metabolic Syndrome and Adipokines Profile in Bipolar Depression.双相抑郁患者的代谢综合征与脂肪因子谱
Nutrients. 2023 Oct 25;15(21):4532. doi: 10.3390/nu15214532.
10
[Relation of serum leptin and adiponectin to cardiovascular risk factors in older adults: a Guangzhou biobank cohort study-CVD].[老年人血清瘦素和脂联素与心血管危险因素的关系：一项广州生物样本库队列研究 - 心血管疾病]
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Feb;31(2):121-5.

引用本文的文献

1
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis.风湿性疾病中的血清脂肪抑制素水平：确定其在类风湿关节炎和轴性脊柱关节炎疾病活动及进展中的作用
Front Immunol. 2025 Aug 6;16:1636158. doi: 10.3389/fimmu.2025.1636158. eCollection 2025.
2
Predicting postpartum female sexual interest/arousal disorder via adiponectin and biopsychosocial factors: a cohort-based decision tree study.通过脂联素和生物心理社会因素预测产后女性性兴趣/性唤起障碍：一项基于队列的决策树研究
Sci Rep. 2025 Jul 27;15(1):27354. doi: 10.1038/s41598-025-12025-3.
3
Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus.

本文引用的文献

1
Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men.生长激素释放肽调节瘦人和超重男性的交感神经系统活动和应激反应。
Hypertension. 2011 Jul;58(1):43-50. doi: 10.1161/HYPERTENSIONAHA.111.171025. Epub 2011 Apr 18.
2
Ghrelin in Type 2 diabetes mellitus and metabolic syndrome.生长激素释放肽在 2 型糖尿病及代谢综合征中的作用。
Mol Cell Endocrinol. 2011 Jun 20;340(1):26-8. doi: 10.1016/j.mce.2011.02.009. Epub 2011 Mar 23.
3
Adiponectin is associated with risk of the metabolic syndrome and insulin resistance in women.
感染人类免疫缺陷病毒者非艾滋病合并症的性别差异
Open Forum Infect Dis. 2021 Nov 3;8(12):ofab558. doi: 10.1093/ofid/ofab558. eCollection 2021 Dec.
4
Association of Serum Adiponectin with Intima Media Thickness of Dorsalis Pedis Artery and Macroangiopathy in Type 2 Diabetes.血清脂联素与 2 型糖尿病患者足背动脉内中膜厚度及大血管病变的关系。
J Diabetes Res. 2020 Jan 3;2020:4739271. doi: 10.1155/2020/4739271. eCollection 2020.
5
Adipokines, metabolic syndrome and rheumatic diseases.脂肪细胞因子、代谢综合征与风湿性疾病。
J Immunol Res. 2014;2014:343746. doi: 10.1155/2014/343746. Epub 2014 Feb 26.
6
A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age.一种 GH/IGF-1 活性降低的 dwarf 小鼠模型，其并不延长寿命：随着年龄的增长，肥胖、瘦素和胰岛素增加的潜在影响。
J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):131-41. doi: 10.1093/gerona/glt069. Epub 2013 May 21.
7
Metabolic syndrome in the offspring of centenarians: focus on prevalence, components, and adipokines.百岁老人后代中的代谢综合征：关注患病率、组成成分及脂肪因子。
Age (Dordr). 2013 Oct;35(5):1995-2007. doi: 10.1007/s11357-012-9483-x. Epub 2012 Nov 9.
脂联素与女性代谢综合征和胰岛素抵抗的风险相关。
Acta Diabetol. 2012 Dec;49 Suppl 1(0 1):S41-9. doi: 10.1007/s00592-010-0192-6. Epub 2010 May 8.
4
Carotid intima media thickness is associated with plasma adiponectin but not with the leptin:adiponectin ratio independently of metabolic syndrome.颈动脉内膜中层厚度与血浆脂联素有关，但与瘦素：脂联素比值无关，且独立于代谢综合征。
Atherosclerosis. 2010 Aug;211(2):393-6. doi: 10.1016/j.atherosclerosis.2010.03.024. Epub 2010 Mar 25.
5
Plasma adiponectin and leptin concentrations in professional rugby players.专业橄榄球运动员的血浆脂联素和瘦素浓度。
J Biol Regul Homeost Agents. 2010 Jan-Mar;24(1):87-91.
6
Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effects of testosterone metabolites.雄激素在血管张力调节中发挥有益作用吗？睾酮代谢物的非基因组血管作用。
Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1301-7. doi: 10.1152/ajpheart.00753.2009. Epub 2010 Mar 12.
7
Long-term effect of a dietary education program on postmenopausal cardiovascular risk and metabolic syndrome: the Brisighella Heart Study.饮食教育计划对绝经后心血管风险和代谢综合征的长期影响：Brisighella 心脏研究。
J Womens Health (Larchmt). 2010 Jan;19(1):133-7. doi: 10.1089/jwh.2008.1268.
8
Leptin receptor modulation of adiposity and fertility.瘦素受体对肥胖和生育的调节作用。
Trends Endocrinol Metab. 2010 Jan;21(1):10-6. doi: 10.1016/j.tem.2009.07.004. Epub 2009 Oct 23.
9
Heart rate, sympathetic cardiovascular influences, and the metabolic syndrome.心率、交感神经对心血管的影响与代谢综合征。
Prog Cardiovasc Dis. 2009 Jul-Aug;52(1):31-7. doi: 10.1016/j.pcad.2009.05.007.
10
Sex-dependent associations of leptin with metabolic syndrome-related variables: the Stanislas study.瘦素与代谢综合征相关变量的性别相关性研究：斯坦尼斯拉斯研究。
Obesity (Silver Spring). 2010 Jan;18(1):196-201. doi: 10.1038/oby.2009.156. Epub 2009 May 14.