Biobehavioral Sciences Department, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
J Cancer Surviv. 2010 Sep;4(3):225-35. doi: 10.1007/s11764-010-0126-x. Epub 2010 May 8.
Beyond documentation of high prevalence rates, research has not examined the qualities and characteristics of musculoskeletal symptoms in cancer survivors, possibly because measures have not been validated specifically for the assessment of these symptoms in survivors. We report here on a new measure of muscle and joint symptoms for survivors of hematologic malignancies and hematopoietic cell transplantation (HCT).
In a cross-sectional design, 130 adults, 5-20 years after HCT, completed patient-reported outcomes. Assessment included musculoskeletal symptoms on the Muscle and Joint Measure (MJM), as well as health-related quality of life and treatments.
Principal components analysis using promax rotation revealed four subscales for the MJM with item factor loadings above 0.50: muscle aches or stiffness (myalgias), joint pain, stiffness or swelling (arthralgias), muscle cramps, and muscle weakness. Variance explained by the total score was 77%. Internal consistency reliabilities of the subscales and total score ranged from 0.86 to 0.93. Validity was confirmed by correlations with the Short Form-36 bodily pain, physical function and vitality subscales, the Fatigue Symptom Inventory, and the Symptom Checklist-90-R depression (all P < .001).
Musculoskeletal symptoms in survivors who received HCT can be measured reliably and validly with the MJM. The measure requires testing to establish its psychometric properties with other diagnostic and treatment groups.
The MJM has potential research and clinical value for addressing the musculoskeletal symptoms of survivors. The measure may assist with examining the mechanisms as well as treatments for these symptoms, which are among the most prevalent in long-term cancer survivors.
除了记录高患病率之外，研究还没有检查癌症幸存者肌肉骨骼症状的质量和特征，这可能是因为没有针对这些症状在幸存者中的评估来验证这些措施。我们在此报告一种新的血液恶性肿瘤和造血细胞移植（HCT）幸存者肌肉和关节症状的测量方法。
在一项横断面设计中，130 名 HCT 后 5-20 年的成年人完成了患者报告的结果。评估包括肌肉骨骼症状的肌肉和关节测量（MJM），以及健康相关的生活质量和治疗。
使用 promax 旋转的主成分分析显示，MJM 有四个亚量表，项目因子负荷高于 0.50：肌肉酸痛或僵硬（肌痛）、关节疼痛、僵硬或肿胀（关节痛）、肌肉痉挛和肌肉无力。总分解释的方差为 77%。亚量表和总分的内部一致性信度范围为 0.86 至 0.93。与简短形式 36 身体疼痛、身体功能和活力分量表、疲劳症状量表和症状清单 90-R 抑郁（均 P <.001）的相关性证实了其有效性。
接受 HCT 的幸存者的肌肉骨骼症状可以用 MJM 可靠且有效地测量。该测量方法需要进行测试，以确定其在其他诊断和治疗组中的心理测量特性。
MJM 具有研究和临床价值，可以解决幸存者的肌肉骨骼症状。该测量方法可能有助于研究这些症状的机制以及治疗方法，这些症状是长期癌症幸存者中最常见的症状之一。
