RAD51 G135C 多态性与乳腺癌易感性相关：一项包含 22399 名受试者的荟萃分析。
RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects.
机构信息
Laboratory of Medical Genetics, Harbin Medical University, Baojian Road 157, Nangang District, Harbin 150081, China.
出版信息
Breast Cancer Res Treat. 2011 Jan;125(1):157-61. doi: 10.1007/s10549-010-0922-z. Epub 2010 May 8.
Several studies have investigated the associations between RAD51 G135C polymorphism and the susceptibility to breast cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 17 case control studies, including 12,153 cases and 10,245 controls, were selected. Overall, significant decreased risk was found for the additive model (OR = 0.995, 95% CI = 0.991-0.998) and dominant model (OR = 0.994, 95% CI = 0.991-0.998). In the subgroup analysis by ethnicity, statistically significantly decreased risk was found in Asians (additive model: OR = 0.977, 95% CI = 0.954-1.000 and dominant model: OR = 0.981, 95% CI = 0.963-1.000). In conclusion, this meta-analysis suggests that the RAD51 G135C polymorphism is a low-penetrant risk factor for developing breast cancer.
已有多项研究探讨了 RAD51 G135C 多态性与乳腺癌易感性之间的关联，但结果尚无定论。为了更准确地评估这种关系，我们进行了荟萃分析。共纳入了 17 项病例对照研究，包括 12153 例病例和 10245 例对照。总体而言，加性模型（OR = 0.995，95%CI = 0.991-0.998）和显性模型（OR = 0.994，95%CI = 0.991-0.998）均提示存在显著的低风险。在按种族亚组分析中，亚洲人群中存在统计学显著的低风险（加性模型：OR = 0.977，95%CI = 0.954-1.000；显性模型：OR = 0.981，95%CI = 0.963-1.000）。综上所述，本荟萃分析提示 RAD51 G135C 多态性是乳腺癌发生的低外显度风险因素。
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