Rad51基因G135C和G172T变异与癌症易感性的关系：一项纳入54项病例对照研究的荟萃分析
Relationship between Rad51 G135C and G172T variants and the susceptibility to cancer: a meta-analysis involving 54 case-control studies.
作者信息
Zhao Mengmeng, Chen Pin, Dong Yanbin, Zhu Xianji, Zhang Xilong
机构信息
Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
出版信息
PLoS One. 2014 Jan 27;9(1):e87259. doi: 10.1371/journal.pone.0087259. eCollection 2014.
BACKGROUND
The associations between Rad51 gene polymorphisms (G135C and G172T) and risk of cancer have been investigated, but the results were inconclusive. To get a comprehensive evaluation of the association above, we performed a meta-analysis of published studies.
METHODS
A computerized search of PubMed, Embase and Web of Knowledge databases for all relevant studies was performed and the data were analyzed in a meta-analysis. The overall odds ratio (OR) with the 95% confidence interval (95% CI) was calculated to assess the strength of the association between Rad51 polymorphisms and cancer risk. Data were analyzed using fixed- or random-effects model when appropriate. Sensitivity analysis and publication bias test were also estimated.
RESULTS
Overall, a total of 54 case-control studies were included in the current meta-analysis, among which 42 studies with 19,142 cases and 20,363 controls for RAD51 G135C polymorphism and 12 studies with 6,646 cases and 6,783 controls for G172T polymorphism. For G135C polymorphism, the pooled results indicated that significantly increased risk was found in overall cancers (homozygote model: OR = 1.776, 95% CI = 1.288-2.449; allelic genetic model: OR = 1.169, 95% CI = 1.016-1.345; recessive model: OR = 1.946, 95% CI = 1.336-2.835), especially in breast cancer (homozygote model: OR = 1.498, 95% CI = 1.026-2.189; recessive model: OR = 1.732, 95% CI = 1.170-2.562). For G172T polymorphism, a decreased cancer risk was observed in head and neck cancer (homozygote model: OR = 0.621, 95% CI = 0.460-0.837; allelic genetic model: OR = 0.824, 95% CI = 0.716-0.948; recessive model: OR = 0.639, 95% CI = 0.488-0.837).
CONCLUSIONS
Our results suggested that the Rad51 G135C polymorphism is a candidate for susceptibility to overall cancers, especially to breast cancer, and that the Rad51 G172T might play a protective role in the development of head and neck cancer.
背景
已对Rad51基因多态性（G135C和G172T）与癌症风险之间的关联进行了研究，但结果尚无定论。为了全面评估上述关联，我们对已发表的研究进行了荟萃分析。
方法
通过计算机检索PubMed、Embase和Web of Knowledge数据库中的所有相关研究，并对数据进行荟萃分析。计算总体比值比（OR）及95%置信区间（95%CI），以评估Rad51基因多态性与癌症风险之间关联的强度。在适当情况下，使用固定效应模型或随机效应模型分析数据。还进行了敏感性分析和发表偏倚检验。
结果
总体而言，本荟萃分析共纳入54项病例对照研究，其中42项研究涉及19142例病例和20363例对照用于RAD51 G135C多态性分析，12项研究涉及6646例病例和6783例对照用于G172T多态性分析。对于G135C多态性，汇总结果表明，在总体癌症中发现风险显著增加（纯合子模型：OR = 1.776，95%CI = 1.288 - 2.449；等位基因遗传模型：OR = 1.169，95%CI = 1.016 - 1.345；隐性模型：OR = 1.946，95%CI = 1.336 - 2.835），尤其是在乳腺癌中（纯合子模型：OR = 1.498，95%CI = 1.026 - 2.189；隐性模型：OR = 1.732，95%CI = 1.170 - 2.562）。对于G172T多态性，在头颈癌中观察到癌症风险降低（纯合子模型：OR = 0.621，95%CI = 0.460 - 0.837；等位基因遗传模型：OR = 0.824，95%CI = 0.716 - 0.948；隐性模型：OR = 0.639，95%CI = 0.488 - 0.837）。
结论
我们的结果表明，Rad51 G135C多态性是总体癌症易感性的一个候选因素，尤其是乳腺癌，而Rad51 G172T可能在头颈癌的发生中起保护作用。
Zotero 插件