Department of Food and Nutrition, Sookmyung Women's University, Seoul, 140-742, South Korea.
Biol Trace Elem Res. 2011 Jun;141(1-3):224-31. doi: 10.1007/s12011-010-8714-1. Epub 2010 May 9.
Manganese (Mn) is an essential element for normal development and bodily functions in humans. In the present study, we examined whether Mn supplementation can alter the serum lipid parameters and liver function in Ca-deficient ovariectomized (OVX) rats. Sixty female Sprague-Dawley rats (6 weeks) were divided into five groups and bred for 12 weeks: sham-operated control group (Sham), OVX Ca deficiency group (OLCa) with Ca-deficient diet (0.1% Ca modified AIN-93N diet), OVX Ca deficiency and Mn supplementation group (OLCaMn), OVX with adequate Ca group (OACa; 0.5% Ca AIN-93N diet), and OVX with adequate Ca and Mn supplementation group (OACaMn). A low Ca diet increased the liver weight and serum levels of GOT, GPT, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in OVX rats. Mn supplementation decreased these parameters in Ca-deficient OVX rat. The results of our study suggest Mn supplementation results in reductions of the blood cholesterol levels, which show an increase due to Ca deficiency in OVX rats.
锰（Mn）是人体正常发育和身体功能所必需的元素。在本研究中，我们研究了补充锰是否可以改变去卵巢（OVX）缺钙大鼠的血清脂质参数和肝功能。将 60 只雌性 Sprague-Dawley 大鼠（6 周龄）分为五组，饲养 12 周：假手术对照组（Sham）、OVX 缺钙组（OLCa），饮食中缺钙（0.1%Ca 改良 AIN-93N 饮食）、OVX 缺钙和锰补充组（OLCaMn）、OVX 充足钙组（OACa；0.5%CaAIN-93N 饮食）和 OVX 充足钙和锰补充组（OACaMn）。低钙饮食增加了 OVX 大鼠的肝重和血清 GOT、GPT、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平。锰补充减少了缺钙 OVX 大鼠的这些参数。我们的研究结果表明，锰补充降低了因 OVX 大鼠缺钙而升高的血液胆固醇水平。
