Department of Internal Medicine and Infectious Diseases, University Hospital of Heraklion, Heraklion 71110, Crete, Greece.
Expert Rev Anti Infect Ther. 2010 May;8(5):529-39. doi: 10.1586/eri.10.29.
Public awareness and advances in the diagnostic approach to Q fever have provided important information on epidemiological and clinical aspects of this zoonosis. Coxiella burnetii infection exhibits various acute or chronic clinical forms, and infection during pregnancy may jeopardize the integrity of the fetus. The presentation of infection is often nonspecific and this hinders prompt diagnosis. Therapeutic regimens vary, and treating Q fever during pregnancy and childhood is often challenging. Increasing clinical experience with C. burnetii infections has helped create treatment protocols and follow-up algorithms that have considerably improved management and prognosis. Vaccines are available, although their use is still limited.
公众意识的提高和对 Q 热诊断方法的改进为这种动物源性传染病的流行病学和临床方面提供了重要信息。贝氏柯克斯体感染表现为各种急性或慢性临床形式，怀孕期间的感染可能危及胎儿的完整性。感染的表现通常是非特异性的，这阻碍了及时诊断。治疗方案各不相同，怀孕期间和儿童时期的 Q 热治疗往往具有挑战性。随着对贝氏柯克斯体感染的临床经验不断增加，已经制定了治疗方案和随访算法，这些方案和算法极大地改善了管理和预后。疫苗是可用的，尽管它们的使用仍然有限。
