Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA.
Ann Med. 2010 May 6;42(4):276-85. doi: 10.3109/07853890903485748.
The experimental data obtained from both human and rodent studies suggest that melatonin may have utility in the treatment of several cardiovascular conditions. In particular, melatonin's use in reducing the severity of essential hypertension should be more widely considered. In rodent studies melatonin has been shown to be highly effective in limiting abnormal cardiac physiology and the loss of critical heart tissue resulting from ischemia/reperfusion injury. Melatonin may also be useful in reducing cardiac hypertrophy in some situations and thereby limiting the frequency of heart failure. Finally, some conventional drugs currently in use have cardiotoxicity as a side-effect. Based on studies in rodents, melatonin, due to its multiple anti-oxidative actions, is highly effective in abrogating drug-mediated damage to the heart. Taken together, the findings from human and animal studies support the consideration of melatonin as a cardioprotective agent.
来自人体和啮齿动物研究的实验数据表明，褪黑素可能在几种心血管疾病的治疗中有应用价值。特别是，褪黑素在降低原发性高血压的严重程度方面的应用应该得到更广泛的考虑。在啮齿动物研究中，褪黑素已被证明在限制异常心脏生理和缺血/再灌注损伤导致的关键心脏组织损失方面非常有效。褪黑素在某些情况下减少心脏肥大也可能有用，从而限制心力衰竭的频率。最后，一些目前使用的常规药物具有心脏毒性作为副作用。基于啮齿动物的研究，褪黑素由于其多种抗氧化作用，在消除药物对心脏的损伤方面非常有效。总之，来自人体和动物研究的发现支持将褪黑素作为一种心脏保护剂的考虑。
