Su Xiaofeng, Liu Jing, Sun Ningling, Huo Yong
Department of Hypertension, Peking University People's Hospital, Beijing, China.
Cardio-Metabolic Laboratory, Peking University People's Hospital, Beijing, China.
Front Cardiovasc Med. 2023 Mar 17;10:1133724. doi: 10.3389/fcvm.2023.1133724. eCollection 2023.
Numerous studies have shown that hyperuricemia (HUA) is associated with cardiovascular and renal outcomes, but few studies specifically explored the effect of age on this relationship. Therefore, our study aimed to explore the relationship between HUA and other cardiometabolic risk factors in different age groups.
This cross-section study used the data from Survey on uric acid in Chinese subjects with essential hypertension (SUCCESS). We performed multivariate logistic regressions in different age groups.
After adjusting for potential confounders, among young and middle-aged adults less than 60, HUA was associated with higher body mass index (BMI, adjusted OR = 1.114, 95% CI: 1.057-1.174), higher fasting blood glucose (FBG, adjusted OR = 1.099, 95% CI: 1.003-1.205), triglycerides (TG, adjusted OR = 1.425, 95% CI: 1.247-1.629), higher low-density lipoprotein cholesterol (LDL-C, adjusted OR = 1.171, 95% CI: 1.025-1.337), and lower estimated glomerular filtration rate (eGFR, adjusted OR = 0.992, 95% CI: 0.988-0.996). Among elderly adults 60 years or older, HUA was associated with higher SBP (adjusted OR = 1.024, 95% CI: 1.005-1.042), higher TG (adjusted OR = 1.716, 95% CI: 1.466-2.009), and higher LDL-C (adjusted OR = 1.595, 95% CI: 1.366-1.863).
HUA is associated with more cardiometabolic risk factors in younger adults with hypertension (HT). Comprehensive management of HT with HUA is needed in clinical settings.
大量研究表明，高尿酸血症（HUA）与心血管和肾脏结局相关，但很少有研究专门探讨年龄对这种关系的影响。因此，我们的研究旨在探讨不同年龄组中HUA与其他心脏代谢危险因素之间的关系。
这项横断面研究使用了中国原发性高血压患者尿酸调查（SUCCESS）的数据。我们在不同年龄组中进行了多变量逻辑回归分析。
在调整潜在混杂因素后，在60岁以下的中青年成年人中，HUA与较高的体重指数（BMI，调整后的OR = 1.114，95% CI：1.057 - 1.174）、较高的空腹血糖（FBG，调整后的OR = 1.099，95% CI：1.003 - 1.205）、甘油三酯（TG，调整后的OR = 1.425，95% CI：1.247 - 1.629）、较高的低密度脂蛋白胆固醇（LDL-C，调整后的OR = 1.171，95% CI：1.025 - 1.337）以及较低的估算肾小球滤过率（eGFR，调整后的OR = 0.992，95% CI：0.988 - 0.996）相关。在60岁及以上的老年人中，HUA与较高的收缩压（SBP，调整后的OR = 1.024，95% CI：1.005 - 1.042）、较高的TG（调整后的OR = 1.716，95% CI：1.466 - 2.009）和较高的LDL-C（调整后的OR = 1.595，95% CI：1.366 - 1.863）相关。
在患有高血压（HT）的年轻成年人中，HUA与更多的心脏代谢危险因素相关。临床环境中需要对HT合并HUA进行综合管理。
