紫外线照射对人体角质层脂质成分的影响。

Influence of UV irradiation on the composition of human stratum corneum lipids.

作者信息

Wefers H, Melnik B C, Flür M, Bluhm C, Lehmann P, Plewig G

机构信息

Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany.

出版信息

J Invest Dermatol. 1991 Jun;96(6):959-62. doi: 10.1111/1523-1747.ep12476124.

DOI:10.1111/1523-1747.ep12476124

PMID:2045684

Abstract

Irradiation with suberythemal doses of either UV-A or UV-B yielded an increase in the amount of stratum corneum lipids extracted from the lumbar skin area of 20 volunteers. These lipids were quantified after separation by high-performance thin-layer chromatography. Ten subfractions in the ceramide region were separated; two of them (fractions 7a and 7b) were only detectable after UV-A or UV-B irradiation. Improvement of barrier function after UV irradiation of human skin with suberythemal doses may be related to an increase in the stratum corneum ceramides.

摘要

用低于红斑量的UV-A或UV-B照射20名志愿者的腰部皮肤区域后，从该区域提取的角质层脂质数量增加。这些脂质通过高效薄层色谱分离后进行定量分析。在神经酰胺区域分离出10个亚组分；其中两个亚组分（7a和7b组分）仅在UV-A或UV-B照射后才可检测到。用低于红斑量的紫外线照射人体皮肤后屏障功能的改善可能与角质层神经酰胺的增加有关。