Department of Veterinary Clinical Science, Section of Internal Medicine, University of Naples Federico II, Via Delpino, 1, 80137 Naples, Italy.
Vet J. 2011 Apr;188(1):118-21. doi: 10.1016/j.tvjl.2010.03.015. Epub 2010 Apr 24.
Thirty naturally infected dogs were divided into three groups (10 animals each): group I (canine leishmaniosis), group II (canine ehrlichiosis) and group III (dogs co-infected by both infectious agents). Ten clinically healthy dogs were used as controls. A haematological profile was obtained and dog sera were assessed for the presence of platelet-bound IgM and IgG antibodies (PBIgM, PBIgG) using flow cytometry. Eight of the naturally co-infected dogs (80%), five of the leishmaniotic dogs (50%) and six of the ehrlichiotic dogs (60%) had detectable levels of platelet-bound antibodies (PBIg). No PBIg were observed in the control group. The hypothesis that Leishmania and Ehrlichia co-infection could more severely affect the immune response of infected dogs is discussed.
三十只自然感染的狗被分为三组（每组 10 只）：I 组（犬利什曼病）、II 组（犬埃立克体病）和 III 组（两种感染因子混合感染的狗）。十只临床健康的狗作为对照组。获得血液学概况，并使用流式细胞术评估狗血清中血小板结合的 IgM 和 IgG 抗体（PBIgM、PBIgG）的存在。在自然混合感染的 8 只狗（80%）、利什曼病的 5 只狗（50%）和埃立克体病的 6 只狗（60%）中检测到血小板结合抗体（PBIg）。对照组未观察到 PBIg。讨论了莱什曼原虫和埃立克体共感染可能更严重影响感染犬免疫反应的假设。
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