Beswick A D, Fehily A M, Sharp D S, Renaud S, Giddings J
MRC Epidemiology Unit, Llandough Hospital, Cardiff, Wales, UK.
J Intern Med. 1991 Jun;229(6):511-5. doi: 10.1111/j.1365-2796.1991.tb00387.x.
Platelet activity was assessed in a sub-sample of 56 participants in the MRC Diet and Reinfarction Trial (DART). Men whose diets contained a high ratio of polyunsaturated to saturated fatty acids (a P:S ratio of greater than 0.5) showed reduced secondary platelet aggregation to adenosine diphosphate (ADP) in platelet-rich plasma (PRP), and diminished platelet aggregation to ADP in whole blood. A trend of reduced secondary platelet aggregation to ADP with increasing dietary eicosapentaenoic acid was noted, but this was not statistically significant. The results of this study and the MRC Diet and Reinfarction Trial suggest a mediatory role for platelet activity in the relationship between diet and ischaemic heart disease.
在医学研究委员会饮食与再梗死试验（DART）的56名参与者子样本中评估了血小板活性。饮食中多不饱和脂肪酸与饱和脂肪酸比例较高（P:S比值大于0.5）的男性，其富含血小板血浆（PRP）中对二磷酸腺苷（ADP）的继发性血小板聚集减少，全血中对ADP的血小板聚集也减少。随着饮食中二十碳五烯酸增加，对ADP的继发性血小板聚集有降低趋势，但这在统计学上无显著意义。本研究结果以及医学研究委员会饮食与再梗死试验表明，血小板活性在饮食与缺血性心脏病的关系中起中介作用。
