Thorngren M, Gustafson A, Wohlfart G
Haemostasis. 1983;13(4):244-7. doi: 10.1159/000214755.
The effect of acetylsalicylic acid (ASA) on platelet aggregation before and during a fish diet, already known to decrease the aggregability of platelets and to prolong the bleeding time, was studied in 10 healthy men. Two doses (3.5 and 10 mg/kg body weight) of ASA were given. Both doses equally decreased platelet aggregation to collagen and adenosine diphosphate (ADP). ASA, taken before the diet, diminished platelet aggregability to ADP by as much as did the diet alone. When ASA was administered during the diet, the effect on platelet aggregability to ADP was additive. Aggregation to collagen also decreased to the same extent as during the baseline period. The results, in conjunction with our earlier ones, indicate that the mechanism by which a fish diet delays primary haemostasis is different from the apparently similar effect of ASA. This raises the possibility of augmenting any antithrombotic effect of ASA by dietary means.
已知鱼类饮食会降低血小板聚集性并延长出血时间，在此期间及之前，研究了乙酰水杨酸（ASA）对10名健康男性血小板聚集的影响。给予两种剂量（3.5和10毫克/千克体重）的ASA。两种剂量均同等程度地降低了血小板对胶原蛋白和二磷酸腺苷（ADP）的聚集性。在饮食前服用ASA，对ADP的血小板聚集性降低程度与单独饮食时相同。当在饮食期间服用ASA时，对ADP的血小板聚集性的影响是相加的。对胶原蛋白的聚集性也降低到与基线期相同的程度。这些结果与我们早期的结果表明，鱼类饮食延迟原发性止血的机制与ASA明显相似的作用不同。这增加了通过饮食手段增强ASA抗血栓作用的可能性。
