低剂量D-青霉胺治疗期间急性病情恶化后硫酸锌治疗威尔逊病

Zinc sulphate therapy for Wilson's disease after acute deterioration during treatment with low-dose D-penicillamine.

作者信息

Veen C, van den Hamer C J, de Leeuw P W

机构信息

Department of Internal Medicine, Zuiderziekenhuis, Rotterdam, The Netherlands.

出版信息

J Intern Med. 1991 Jun;229(6):549-52. doi: 10.1111/j.1365-2796.1991.tb00395.x.

DOI:10.1111/j.1365-2796.1991.tb00395.x

PMID:2045766

Abstract

A 30-year-old woman with Wilson's disease was treated with low-dose D-penicillamine. After 12 days, treatment was changed to zinc sulphate because of severe neurological deterioration. The patient subsequently improved within a few days. During a follow-up period of 20 months, the effectiveness of therapy was evaluated by measuring copper and zinc levels in plasma and urine, and by 64Cu-loading tests. We conclude that sulphate therapy may be a satisfactory alternative, even when rapid deterioration occurs in the early stages of D-penicillamine treatment.

摘要

一名患有威尔逊氏病的30岁女性接受了低剂量D-青霉胺治疗。12天后，由于严重的神经功能恶化，治疗改为硫酸锌。患者随后在几天内病情好转。在20个月的随访期内，通过测量血浆和尿液中的铜和锌水平以及64Cu负荷试验来评估治疗效果。我们得出结论，即使在D-青霉胺治疗早期出现快速恶化的情况下，硫酸锌治疗也可能是一种令人满意的替代方案。