Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey.
Cornea. 2010 Jun;29(6):659-63. doi: 10.1097/ICO.0b013e3181c296ab.
To determine the prevalence of pinguecula and pterygium in patients with thyroid orbitopathy (TO) and to evaluate its correlation with clinical findings.
All patients underwent a thorough ophthalmic examination, including tear function analysis using tear film breakup time (BUT) measurement. For patients with TO, lid retraction, Hertel exophthalmometry, and clinical activity scores were also measured. All patients were evaluated for the presence of pinguecula and pterygium.
The groups were age (P = 0.15) and gender matched (P = 0.2). The prevalence of pinguecula was significantly higher in group 1 (196 patients, 98%) than in group 2 (23 patients, 46%) and group 3 (64 patients, 32%) (P < 0.001). In group 1, lid retraction was significantly correlated with pinguecula prevalence (P < 0.001), whereas there was no correlation between pinguecula prevalence and BUT values (P = 0.624), clinical activity score levels (P = 0.325), or exophthalmometer findings (P = 0.155) In groups 2 and 3, pinguecula was seen more frequently in patients with subnormal BUT measurements (P < 0.001). Pterygium was seen at very low rates in all groups and analysis could not be performed.
Pinguecula was seen more frequently in patients with TO than in both control groups. Lid retraction was the only clinical factor determined with significant impact on the prevalence of pinguecula in patients with TO. Impaired tear function did not influence pinguecula prevalence in patients with TO, in contrast to both control groups. Increased exposure to UV light because of lid retraction may be the major underlying causative factor on pinguecula prevalence in patients with TO, compared with tear dysfunction in both control groups.
确定甲状腺眼病（TO）患者中翼状胬肉和结膜下黄色瘤的患病率，并评估其与临床发现的相关性。
所有患者均接受全面眼科检查，包括使用泪膜破裂时间（BUT）测量进行泪液功能分析。对于 TO 患者，还测量了眼睑退缩、Hertel 突眼计和临床活动评分。评估所有患者是否存在翼状胬肉和结膜下黄色瘤。
年龄（P=0.15）和性别（P=0.2）在两组间匹配。第 1 组（196 例患者，98%）中翼状胬肉的患病率明显高于第 2 组（23 例患者，46%）和第 3 组（64 例患者，32%）（P＜0.001）。在第 1 组中，眼睑退缩与翼状胬肉患病率显著相关（P＜0.001），而翼状胬肉患病率与 BUT 值（P=0.624）、临床活动评分水平（P=0.325）或突眼计检查结果（P=0.155）之间无相关性。在第 2 组和第 3 组中，BUT 值异常的患者中更常出现翼状胬肉（P＜0.001）。所有组中均很少见翼状胬肉，无法进行分析。
与对照组相比，TO 患者中更常出现翼状胬肉。眼睑退缩是唯一对 TO 患者中翼状胬肉患病率有显著影响的临床因素。与对照组相比，泪液功能障碍不会影响 TO 患者中翼状胬肉的患病率。由于眼睑退缩导致暴露于紫外线增加，可能是与对照组的泪液功能障碍相比，TO 患者中翼状胬肉患病率增加的主要潜在致病因素。
