Variation Biotechnologies Inc., Ottawa, Ontario, Canada.
Immunol Cell Biol. 2011 Jan;89(1):81-9. doi: 10.1038/icb.2010.65. Epub 2010 May 11.
The application of the fields of pharmacogenomics and pharmacogenetics to vaccine design has been recently labeled 'vaccinomics'. This newly named area of vaccine research, heavily intertwined with bioinformatics, seems to be leading the charge in developing novel vaccines for currently unmet medical needs against hypervariable viruses such as human immunodeficiency virus (HIV), hepatitis C and emerging avian and swine influenza. Some of the more recent bioinformatic approaches in the area of vaccine research include the use of epitope determination and prediction algorithms for exploring the use of peptide epitopes as vaccine immunogens. This paper briefly discusses and explores some current uses of bioinformatics in vaccine design toward the pursuit of peptide vaccines for hypervariable viruses. The various informatics and vaccine design strategies attempted by other groups toward hypervariable viruses will also be briefly examined, along with the strategy used by our group in the design and synthesis of peptide immunogens for candidate HIV and influenza vaccines.
近年来，药物基因组学和药物遗传学在疫苗设计中的应用被称为“疫苗组学”。这个新的疫苗研究领域与生物信息学紧密交织，似乎正在引领针对目前无法满足的医疗需求的新型疫苗的开发，针对的是高度变异的病毒，如人类免疫缺陷病毒 (HIV)、丙型肝炎和新兴的禽流感和猪流感。疫苗研究领域中的一些最近的生物信息学方法包括使用表位确定和预测算法来探索将肽表位用作疫苗免疫原。本文简要讨论和探讨了生物信息学在疫苗设计中的一些当前用途，以追求针对高度变异病毒的肽疫苗。还将简要检查其他小组针对高度变异病毒尝试的各种信息学和疫苗设计策略，以及我们小组在设计和合成候选 HIV 和流感疫苗的肽免疫原方面使用的策略。
