Mitz A R, Godschalk M, Wise S P
Laboratory of Neurophysiology, National Institute of Mental Health, Poolesville, Maryland 20837.
J Neurosci. 1991 Jun;11(6):1855-72. doi: 10.1523/JNEUROSCI.11-06-01855.1991.
It has been proposed that the premotor cortex plays a role in the selection of motor programs based on environmental context. To test this hypothesis, we recorded the activity of single neurons as monkeys learned visuomotor associations. The hypothesis predicts that task-related premotor cortical activity before learning should differ from that afterward. We found that a substantial population of premotor cortex neurons, over half of those adequately tested, showed the predicted learning-dependent changes in activity. The present findings support a role for premotor cortex in motor preparation, generally, and suggest a specific role in the selection of movements on the basis of arbitrary associations.
有人提出，运动前区皮层在基于环境背景选择运动程序中发挥作用。为了验证这一假设，我们在猴子学习视觉运动关联时记录了单个神经元的活动。该假设预测，学习前与任务相关的运动前区皮层活动应与学习后不同。我们发现，大量运动前区皮层神经元（在充分测试的神经元中超过半数）表现出了预测的与学习相关的活动变化。目前的研究结果总体上支持运动前区皮层在运动准备中的作用，并表明其在基于任意关联选择运动方面具有特定作用。
