University of Kansas, KU Bioengineering Research Center, Department of Mechanical Engineering, 1530 West 15th Street, Lawrence, Kansas 66045, USA.
J Biomed Opt. 2010 Mar-Apr;15(2):021312. doi: 10.1117/1.3365948.
We have developed an integrated photoacoustic imaging (PAI) and high-intensity focused ultrasound (HIFU) system for solid tumor treatments. A single-element, spherically focused ultrasonic transducer, with a central frequency of 5 MHz, was used to induce HIFU lesions in soft tissue. The same ultrasonic transducer was also used as a detector during PAI to guide HIFU ablation. The use of same transducer for PAI and HIFU can reduce the requirement on acoustic windows during the imaging-guided therapy, as well as ensuring the correct alignment between the therapeutic beam and the planned treatment volume. During an experiment, targeted soft tissue was first imaged by PAI. The resulted image was used to plan the subsequent HIFU ablation. After the HIFU ablation, targeted soft tissue was imaged again by PAI to evaluate the effectiveness of treatments. Good contrast was obtained between photoacoustic images before and after HIFU ablation. In conclusion, our results demonstrated that PAI technology may potentially be integrated with HIFU ablation for image-guided therapy.
我们开发了一种集成的光声成像（PAI）和高强度聚焦超声（HIFU）系统，用于治疗实体瘤。使用单个元件、球形聚焦超声换能器，中心频率为 5MHz，用于在软组织中产生 HIFU 损伤。同一超声换能器也在 PAI 期间用作探测器，以引导 HIFU 消融。在成像引导治疗期间，同一换能器用于 PAI 和 HIFU 可以减少对声窗的要求，并确保治疗光束与计划的治疗体积之间的正确对准。在实验中，首先通过 PAI 对靶向软组织进行成像。所得到的图像用于规划随后的 HIFU 消融。在 HIFU 消融之后，再次通过 PAI 对靶向软组织进行成像，以评估治疗效果。在 HIFU 消融前后的光声图像之间获得了良好的对比。总之，我们的结果表明，PAI 技术可能与 HIFU 消融相结合，用于图像引导治疗。
