实时光声传感用于光介导的超声治疗。
Real-time photoacoustic sensing for photo-mediated ultrasound therapy.
出版信息
Opt Lett. 2019 Aug 15;44(16):4063-4066. doi: 10.1364/OL.44.004063.
Abstract
Photo-mediated ultrasound therapy (PUT) is a novel, noninvasive antimicrovascular approach that can treat neovascularization with high precision. We developed a photoacoustic (PA) sensing (PAS) system for PUT and achieved real-time PAS-guided PUT. Experiments performed on a chicken yolk sac membrane model demonstrated that PAS could monitor the treatment effect in a microvessel during PUT. Vessel shrinkage induced a decrease in the PA signal amplitude, while vessel rupture induced an abrupt increase in the PA signal amplitude. The integrated PUT and PAS system can significantly improve the safety and effectiveness of PUT, and may assist with clinical translation of this novel antimicrovascular technique.
摘要
光介导超声治疗（PUT）是一种新颖的、非侵入性的抗微血管方法，能够实现高精度的新生血管治疗。我们开发了一种光声（PA）传感（PAS）系统用于 PUT，并实现了实时 PAS 引导的 PUT。在鸡黄囊膜模型上进行的实验表明，PAS 可在 PUT 过程中监测微血管的治疗效果。血管收缩会导致 PA 信号幅度降低，而血管破裂会导致 PA 信号幅度急剧增加。集成的 PUT 和 PAS 系统可以显著提高 PUT 的安全性和有效性，并可能有助于该新型抗微血管技术的临床转化。
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