Debongnie J C, Pauwels S, Raat A, de Meeus Y, Haot J, Mainguet P
Department of Nuclear Medicine, University of Louvain Medical School, Brussels, Belgium.
J Nucl Med. 1991 Jun;32(6):1192-8.
Gastric urease was studied isotopically in 230 patients with biopsy-proven normal mucosa or chronic gastritis, including 59 patients with ulcer disease. Carbon-14-urea was given in 25 ml of water without substrate carrier or nutrient-dense meal, and breath samples were collected over a 60-min period. The amount of 14CO2 excreted at 10 min was independent of the rate of gastric emptying and was not quantitatively influenced by the buccal urease activity. The 10-min 14CO2 values discriminated well between Helicobacter pylori positive and negative patients (94% sensitivity, 89% specificity) and correlated with the number of organisms assessed by histology. The test was a good predictor of chronic gastritis (95% sensitivity and 96% specificity), and a quantitative relationship was observed between 14CO2 values and the severity and activity of the gastritis. In H. pylori positive patients, breath 14CO2 was found to be similar in patients with and without ulcer disease, suggesting that the number of bacteria is not a determining factor for the onset of ulceration.
对230例经活检证实为正常黏膜或慢性胃炎的患者进行了胃尿素酶的同位素研究，其中包括59例溃疡病患者。将25毫升水中的碳-14尿素在无底物载体或营养丰富餐食的情况下给予患者，并在60分钟内收集呼气样本。10分钟时呼出的14CO2量与胃排空速率无关，且不受口腔尿素酶活性的定量影响。10分钟时的14CO2值能很好地区分幽门螺杆菌阳性和阴性患者（敏感性94%，特异性89%），并与通过组织学评估的细菌数量相关。该检测是慢性胃炎的良好预测指标（敏感性95%，特异性96%），并且观察到14CO2值与胃炎的严重程度和活动度之间存在定量关系。在幽门螺杆菌阳性患者中，有溃疡病和无溃疡病患者的呼气14CO2相似，这表明细菌数量不是溃疡发生的决定因素。
