Pathology Division, Research Centre for Innovative Oncology, National Cancer Centre at Kashiwa, Chiba, Japan.
Histopathology. 2010 Mar;56(4):510-22. doi: 10.1111/j.1365-2559.2010.03512.x.
Superficial squamous epithelial lesions of the pharynx are increasingly recognized by architectural changes in the intraepithelial papillary capillary loop (IPCL) assessed by narrow-band imaging (NBI). The aim was to explore the histology of squamous epithelial precursor lesions and superficial-type pharyngeal squamous cell carcinoma (STPSCC), including squamous cell carcinoma (SCC) in situ and early invasive SCC, by focusing on microvascular irregularities to investigate the composition of those lesions and to explore the pathological characteristics of STPSCCs.
Several pathological factors including thickness of intraepithelial squamous cell carcinoma (IESCC) and tumour thickness and microvascular density (MVD) were examined in 104 STPSCCs from 69 patients. The results show that architectural change of IPCL was recognized in precursor lesions in parallel with architectural disturbance and cytological atypia for criteria of diagnosing dysplasia. In 104 STPSCCs, the MVD of IESCC was correlated with the thickness of IESCC (P = 0.0115). Moreover, invasive SCC showed significantly higher MVD of IESCC (P = 0.0078) and there was significant correlation between the thickness of IESCC and subepithelial invasion (P < 0.0001).
Microvascular irregularities are an important pathological factor in carcinogenesis and early invasiveness of SCC of the pharynx.
通过窄带成像（NBI）评估上皮内乳头状毛细血管环（IPCL）的结构变化，越来越多地认识到咽部浅表鳞状上皮病变。目的是通过关注微血管不规则性来探讨鳞状上皮前体病变和浅表型咽鳞状细胞癌（STPSCC）的组织学，包括原位鳞状细胞癌和早期浸润性鳞状细胞癌，以研究这些病变的组成并探讨 STPSCC 的病理特征。
在 69 例患者的 104 例 STPSCC 中，检查了几个病理因素，包括上皮内鳞状细胞癌（IESCC）的厚度、肿瘤厚度和微血管密度（MVD）。结果表明，在伴有结构紊乱和细胞学异型性的前驱病变中，可识别 IPCL 的结构变化，这些是诊断异型增生的标准。在 104 例 STPSCC 中，IESCC 的 MVD 与 IESCC 的厚度相关（P = 0.0115）。此外，浸润性 SCC 的 IESCC 的 MVD 显著更高（P = 0.0078），并且 IESCC 的厚度与上皮下浸润之间存在显著相关性（P < 0.0001）。
微血管不规则性是咽部 SCC 发生和早期浸润的一个重要病理因素。
