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脂质蓄积产物对中国一般人群代谢综合征识别的预测价值增强。

Enhanced Predictive Value of Lipid Accumulation Product for Identifying Metabolic Syndrome in the General Population of China.

机构信息

Key Laboratory of Public Health Safety of Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.

Zhongshan Community Health Center, Shanghai 201613, China.

出版信息

Nutrients. 2023 Jul 17;15(14):3168. doi: 10.3390/nu15143168.

Abstract

The purpose of this research was to evaluate the lipid accumulation product (LAP)'s accuracy and predictive value for identifying metabolic syndrome (MS) in the general Chinese population compared with other obesity indicators. Baseline survey information from a population-based cohort study carried out in Shanghai's Songjiang District was used in this research. Odds ratios (OR) and a 95% confidence interval (CI) were obtained by logistic regression. The ability of each variable to detect MS was assessed using the receiver operating characteristic curve (ROC). The optimum cut-off point for each indicator was selected using Youden's index. The survey involved 35,446 participants in total. In both genders, the prevalence of MS rose as the LAP increased ( < 0.001). The LAP's AUC was 0.901 (95%CI: 0.895-0.906) in males and 0.898 (95%CI: 0.893-0.902) in females, making it substantially more predictive of MS than other variables (BMI, WC, WHR, WHtR). The optimal cutoff point of the LAP for men and women was 36.04 (Se: 81.91%, Sp: 81.06%) and 34.95 (Se: 80.93%, Sp: 83.04%). The Youden index of the LAP was 0.64 for both sexes. Our findings imply that the LAP, compared to other obesity markers in China, is a more accurate predictor of MS.

摘要

本研究旨在评估脂联素(LAP)在识别中国一般人群代谢综合征(MS)方面的准确性和预测价值,并将其与其他肥胖指标进行比较。本研究使用了在上海市松江区进行的一项基于人群的队列研究的基线调查信息。通过逻辑回归获得比值比(OR)和 95%置信区间(CI)。使用受试者工作特征曲线(ROC)评估每个变量识别 MS 的能力。使用 Youden 指数选择每个指标的最佳截断点。该调查共涉及 35446 名参与者。在男女两性中,随着 LAP 的增加,MS 的患病率呈上升趋势(<0.001)。LAP 在男性中的 AUC 为 0.901(95%CI:0.895-0.906),在女性中为 0.898(95%CI:0.893-0.902),明显优于其他变量(BMI、WC、WHR、WHtR)。LAP 对男性和女性 MS 的最佳截断点分别为 36.04(Se:81.91%,Sp:81.06%)和 34.95(Se:80.93%,Sp:83.04%)。LAP 的男女两性的 Youden 指数均为 0.64。我们的研究结果表明,与中国其他肥胖标志物相比,LAP 是 MS 的更准确预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1da/10383986/fbd7642b77d2/nutrients-15-03168-g001.jpg

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