Zhu Xianlin, Wang Peng, Yue Ya, Wu Tiancheng, Cui Jiali, Shu Yanping, Ma Ling
Department of Clinical Psychology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Department of Neurology, Anqing Municipal Hospital, Anqing, China.
Front Psychiatry. 2024 Jul 8;15:1395766. doi: 10.3389/fpsyt.2024.1395766. eCollection 2024.
Lipid Accumulation Product (LAP) is a new type of obesity index. The relationship between LAP and depression is unclear, and this cross-sectional study was conducted to explore the relationship between LAP and depression using the National Health and Nutrition Examination Survey (NHANES) database from 2005-2018.
In our study, logistic regression analysis was used to calculate the odds ratio between depression and LAP, and subgroup analysis and sensitivity analysis were also performed to verify the robustness of the results.
The analysis included 13,240 participants aged 20 years or older. After adjusting for multiple variables, LAP was positively associated with depression, OR 1. 50 (95% CI, 1. 05-2. 12). In subgroup analysis, LAP was significantly positively, associated with depression among male (2. 52, OR; 95% CI, 1. 39,4. 57), non-Hispanic Black (2. 55, OR; 95% CI, 1. 49,4. 36), those without diabetes (1. 67, OR; 95% CI, (1. 06,2. 61) or in the overweight (2. 09, OR; 95% CI, (1. 23,3. 54) subgroups. After inverse probability of treatment weighting (IPTW), the OR for the highest versus lowest quartile was 1. 55 (95% CI: 1. 24 - 1. 95).
There are positive results between LAP and depression after adjusting for multiple potential variables, and prospective studies are needed to verify the results.
脂质蓄积产物（LAP）是一种新型肥胖指数。LAP与抑郁症之间的关系尚不清楚，本横断面研究利用2005 - 2018年美国国家健康与营养检查调查（NHANES）数据库探讨LAP与抑郁症之间的关系。
在我们的研究中，采用逻辑回归分析计算抑郁症与LAP之间的比值比，并进行亚组分析和敏感性分析以验证结果的稳健性。
分析纳入了13240名20岁及以上的参与者。在调整多个变量后，LAP与抑郁症呈正相关，比值比为1.50（95%置信区间，1.05 - 2.12）。在亚组分析中，LAP与男性（比值比2.52；95%置信区间，1.39 - 4.57）、非西班牙裔黑人（比值比2.55；95%置信区间，1.49 - 4.36）、无糖尿病者（比值比1.67；95%置信区间，1.06 - 2.61）或超重亚组（比值比2.09；95%置信区间，1.23 - 3.54）中的抑郁症显著正相关。在采用治疗权重逆概率（IPTW）后，最高四分位数与最低四分位数的比值比为1.55（95%置信区间：1.24 - 1.95）。
在调整多个潜在变量后，LAP与抑郁症之间存在正相关结果，需要进行前瞻性研究以验证该结果。
