弧菌染色体具有共同的历史。
Vibrio chromosomes share common history.
机构信息
Dept, of Civil and Environmental Engineering, 15 Vassar Street, Cambridge, MA 02139, USA.
出版信息
BMC Microbiol. 2010 May 10;10:137. doi: 10.1186/1471-2180-10-137.
BACKGROUND
While most gamma proteobacteria have a single circular chromosome, Vibrionales have two circular chromosomes. Horizontal gene transfer is common among Vibrios, and in light of this genetic mobility, it is an open question to what extent the two chromosomes themselves share a common history since their formation.
RESULTS
Single copy genes from each chromosome (142 genes from chromosome I and 42 genes from chromosome II) were identified from 19 sequenced Vibrionales genomes and their phylogenetic comparison suggests consistent phylogenies for each chromosome. Additionally, study of the gene organization and phylogeny of the respective origins of replication confirmed the shared history.
CONCLUSIONS
Thus, while elements within the chromosomes may have experienced significant genetic mobility, the backbones share a common history. This allows conclusions based on multilocus sequence analysis (MLSA) for one chromosome to be applied equally to both chromosomes.
背景
虽然大多数γ变形菌只有一条环状染色体，但弧菌科却有两条环状染色体。弧菌中普遍存在水平基因转移，鉴于这种遗传可移动性，这两个染色体本身在形成后是否具有共同的历史，这是一个悬而未决的问题。
结果
从 19 个已测序的弧菌类基因组中鉴定出每个染色体的单拷贝基因（I 染色体上的 142 个基因和 II 染色体上的 42 个基因），它们的系统发育比较表明每个染色体的系统发育一致。此外，对复制起始原点的基因组织和系统发育的研究证实了它们具有共同的历史。
结论
因此，尽管染色体内部的某些元素可能经历了显著的遗传可移动性，但它们的骨架却有着共同的历史。这使得基于多位点序列分析（MLSA）的一个染色体的结论同样适用于两条染色体。
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