Varga J, Haustein U F, Creech R H, Dwyer J P, Jimenez S A
Department of Medicine, Jefferson Medical College, Philadelphia, Pa.
JAMA. 1991 Jun 26;265(24):3292-5.
Four patients with stable systemic sclerosis and limited skin involvement received radiation for the treatment of solid malignant neoplasms. Following localized irradiation, each patient developed an exaggerated cutaneous and internal fibrotic reaction in the irradiated areas. The surface area of fibrosis extended beyond the radiation portals employed, and the fibrotic process was poorly responsive to antifibrotic therapy. Three of the patients died of complications caused by fibrous encasement of internal organs. The extent and severity of postradiation fibrosis in these patients was distinctly unusual. These observations suggest that patients with systemic sclerosis are particularly susceptible to developing excessive radiation-induced fibrosis.
4例患有稳定型系统性硬化症且皮肤受累有限的患者接受了针对实体恶性肿瘤的放射治疗。局部照射后，每位患者在照射区域均出现了过度的皮肤和内部纤维化反应。纤维化的表面积超出了所使用的放射野范围，并且纤维化过程对抗纤维化治疗反应不佳。3例患者死于内部器官纤维包裹引起的并发症。这些患者放射后纤维化的程度和严重性明显异常。这些观察结果表明，系统性硬化症患者特别容易发生过度的辐射诱导纤维化。
