Allergy and Immunology Service, Clinica El Avila, Caracas, Venezuela.
J Investig Allergol Clin Immunol. 2010;20(2):139-45.
An increased prevalence of atopy has been observed in patients with intolerance of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).
To investigate total and mite-specific immunoglobulin (Ig) E in serum from patients with hypersensitivity to NSAIDs and healthy controls.
Patients who reacted to 2 or more chemically unrelated NSAIDs with urticaria and angioedema, confirmed by a double-blinded provocation test with aspirin, were skin tested with inhalant allergens. Total and specific IgE to Dermatophagoides pteronyssinus (Dp) and Blomia tropicalis (Bt) in the serum was quantified by enzyme-linked immunosorbent assay (ELISA) in patients and a control group of healthy blood donors.
One-hundred-and-fourteen patients and 74 controls were studied. Skin tests were positive in 95 patients (83.3%). Total mean IgE levels were 107.1 (91.3) IU/mL in controls and 161.0 (150.8) IU/mL in patients (P = .006). Mean (SD) levels of IgE to Dp were 0.210 (0.17) optical density (OD) units in controls and 0.473 (0.65) OD units in patients (P = .001). Levels of specific IgE to Bt were 0.230 (0.20) OD units in controls and 0.522 (0.8) OD units in patients (P =.0001). Positive ELISA results for IgE to Dp were found for 29.6% of controls and 70.4% of patients (P =.0001); the corresponding percentages for Bt were 32.4% of controls and 67.6 % of patients (P = .0001).
Cross-reactive patients with NSAID-induced urticaria and angioedema exhibit an increased prevalence of sensitization to Dp and Bt and increased total serum IgE. Further research is necessary to determine the reasons for this association.
在对阿司匹林和非甾体抗炎药（NSAIDs）不耐受的患者中，观察到过敏的患病率增加。
研究对 NSAIDs 过敏的患者和健康对照者血清中的总免疫球蛋白（Ig）E 和螨特异性 IgE。
通过对 2 种或更多种化学上无关的 NSAIDs 过敏的患者进行双盲激发试验，并用阿司匹林进行确认，对这些患者进行吸入性过敏原皮肤点刺试验。通过酶联免疫吸附试验（ELISA），在患者和健康献血者对照组中定量检测血清中对屋尘螨（Dp）和粉尘螨（Bt）的总 IgE 和特异性 IgE。
共研究了 114 例患者和 74 例对照者。95 例患者（83.3%）皮肤点刺试验阳性。对照组的总 IgE 平均水平为 107.1（91.3）IU/mL，患者组为 161.0（150.8）IU/mL（P =.006）。对照组的 IgE 对 Dp 的平均（SD）水平为 0.210（0.17）光密度（OD）单位，患者组为 0.473（0.65）OD 单位（P =.001）。对照组特异性 IgE 对 Bt 的水平为 0.230（0.20）OD 单位，患者组为 0.522（0.8）OD 单位（P =.0001）。对照组中 IgE 对 Dp 的 ELISA 阳性结果为 29.6%，患者组为 70.4%（P =.0001）；对照组中 IgE 对 Bt 的阳性结果为 32.4%，患者组为 67.6%（P =.0001）。
交叉反应性 NSAID 诱导性荨麻疹和血管性水肿患者对 Dp 和 Bt 的致敏率增加，总血清 IgE 增加。需要进一步研究确定这种关联的原因。
