Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Xi'an 710069, China.
J Mol Neurosci. 2010 Sep;42(1):120-6. doi: 10.1007/s12031-010-9373-6. Epub 2010 May 13.
Some genes involved in neurotransmission synthesis and transmission have been hypothesized to affect personality traits. To investigate the possible roles of these genes in personality traits of 16 Personality Factor Questionnaire, we performed a population-based study in a young Chinese Han cohort. In the study, we selected some functional variations in ten candidate genes (COMT, DBH, DRD(2), DRD(3), DAT, MAOA, GRM(1), GRIN2B, 5-TH(2A), and 5-TH(6)) encoding components in dopamine, glutamate, and 5-hydroxytryptamine pathways. The results showed the T102C in 5-TH(2A) was associated with X3 (emotional and quiet alertness) and B (reasoning) (F = 4.71 and 6.23; p = 0.009 and 0.002), Val158Met in COMT with E (dominance) (F = 7.01; p = 0.0009), while the variations in DBH, DRD(2), DRD(3), MAOA, GRM(1), GRIN2B, and 5-TH(6) were not associated with any of the personality traits. This finding suggests that T102C in 5-TH(2A) and Val158Met in COMT play roles in some human personality traits.
一些涉及神经递质合成和传递的基因被假设影响人格特质。为了研究这些基因在 16 种人格因素问卷人格特质中的可能作用，我们在中国汉族青年人群中进行了一项基于人群的研究。在这项研究中，我们选择了十个候选基因（COMT、DBH、DRD(2)、DRD(3)、DAT、MAOA、GRM(1)、GRIN2B、5-TH(2A)和 5-TH(6)）中一些与多巴胺、谷氨酸和 5-羟色胺通路相关的功能变异。结果表明，5-TH(2A)中的 T102C 与 X3（情绪和安静警觉）和 B（推理）（F = 4.71 和 6.23；p = 0.009 和 0.002）有关，COMT 中的 Val158Met 与 E（支配）（F = 7.01；p = 0.0009）有关，而 DBH、DRD(2)、DRD(3)、MAOA、GRM(1)、GRIN2B 和 5-TH(6)的变异与任何人格特质都没有关系。这一发现表明，5-TH(2A)中的 T102C 和 COMT 中的 Val158Met 在内的一些基因在某些人类人格特质中发挥作用。
