Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
J Mol Neurosci. 2011 May;44(1):48-52. doi: 10.1007/s12031-011-9505-7. Epub 2011 Mar 3.
The 32-kDa dopamine- and cAMP-regulated phosphoprotein (DARPP-32) is a key signaling factor in several neurotransmitter pathways (including dopamine and serotonin) that impact personality traits. Therefore, different DARPP-32 alleles may influence the biological determination of distinct personality types. We established an association between the DARPP-32 gene polymorphisms (rs12601930C/T, rs879606A/G, and rs3764352A/G) and personality traits as measured by the Tridimensional Personality Questionnaire in 502 healthy Chinese-Han subjects. Of the three polymorphic sites examined, rs12601930C/T was associated with novelty seeking (χ² = 13.06, P = 0.001), while both rs879606A/G and rs3764352A/G were associated with harm avoidance (rs879606: χ² = 7.74, P = 0.021; rs3764352: χ² = 8.53, P = 0.014). There was no significant association between reward dependence scores and DARPP-32 gene polymorphisms. Our results suggest that polymorphisms in the DARPP-32 gene are involved in the biological mechanisms that confer the traits of novelty seeking and harm avoidance.
32kDa 多巴胺和 cAMP 调节磷酸蛋白（DARPP-32）是几种神经递质途径（包括多巴胺和血清素）中的关键信号因子，这些途径会影响个性特征。因此，不同的 DARPP-32 等位基因可能会影响不同人格类型的生物学决定因素。我们通过对 502 名健康汉族个体进行三维人格问卷测量，建立了 DARPP-32 基因多态性（rs12601930C/T、rs879606A/G 和 rs3764352A/G）与人格特质之间的关联。在所检查的三个多态性位点中，rs12601930C/T 与寻求新奇有关（χ²=13.06，P=0.001），而 rs879606A/G 和 rs3764352A/G 均与回避伤害有关（rs879606：χ²=7.74，P=0.021；rs3764352：χ²=8.53，P=0.014）。奖赏依赖评分与 DARPP-32 基因多态性之间没有显著关联。我们的研究结果表明，DARPP-32 基因的多态性参与了赋予寻求新奇和回避伤害特质的生物学机制。
