Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Xi'an, 710069, China.
Cell Mol Neurobiol. 2011 May;31(4):519-26. doi: 10.1007/s10571-010-9645-2. Epub 2011 Jan 15.
Reasoning skill is an advanced cognitive ability which is needed for drawing inferences from given information. It is well known that the ability depends on the neural network of the frontal and parietal brain regions. In this study, we hypothesized that some genes involved in neurotransmitter systems were related to reasoning skill. To confirm this hypothesis, we examined the effects of 13 genes (BDNF, NRSF, COMT, DBH, DRD(2), DRD(3), DAT(1), MAOA, GRM(1), GRIN2B, TPH(2), 5-HT(2A), and 5-HT(6)) in neurotransmitter systems on the non-verbal reasoning and verbal reasoning skills. The results indicated there were on significant effects of the 17 functional variants of these genes on the performance of non-verbal reasoning and verbal analogical reasoning skills (χ(2) > 3.84, df = 1, P > 0.05). This study suggests that some of the functional variations in BDNF, COMT, DBH, DRD(2), DRD(3), MAOA, 5-HT(2A), 5-HT(6), GRM(1), and GRIN2B have no observable effects on the certain reasoning skills in a young healthy Chinese Han population.
推理能力是一种高级认知能力，需要从给定的信息中进行推理。众所周知，这种能力取决于额叶和顶叶脑区的神经网络。在这项研究中，我们假设一些涉及神经递质系统的基因与推理能力有关。为了证实这一假设，我们研究了 13 个基因（BDNF、NRSF、COMT、DBH、DRD(2)、DRD(3)、DAT(1)、MAOA、GRM(1)、GRIN2B、TPH(2)、5-HT(2A)和 5-HT(6))在神经递质系统对非言语推理和言语推理技能的影响。结果表明，这些基因的 17 个功能变体对非言语推理和言语类比推理技能的表现没有显著影响（χ(2) > 3.84，df = 1，P > 0.05）。本研究表明，BDNF、COMT、DBH、DRD(2)、DRD(3)、MAOA、5-HT(2A)、5-HT(6)、GRM(1)和 GRIN2B 的一些功能变异在年轻健康的汉族人群中对某些推理技能没有可观察到的影响。
