University of Michigan, Ann Arbor, USA.
Curr Atheroscler Rep. 2010 Jul;12(4):267-72. doi: 10.1007/s11883-010-0112-9.
Metabolites reflect the dynamic processes underlying cellular homeostasis. Recent advances in analytical chemistry and molecular biology have set the stage for metabolite profiling to help us understand complex molecular processes and physiology. Metabolomics is the comparative analysis of metabolite flux and how it relates to biological phenotypes. As an intermediate phenotype, metabolite signatures capture a unique aspect of cellular dynamics that is not typically interrogated, providing a distinct perspective on cellular homeostasis. To date, there have been only a few metabolomics studies investigating cardiovascular diseases. In this review, we explore the principles of metabolomics and how it can provide further insight into the mechanisms of cardiovascular physiology and ultimately lead to improved diagnostic and therapeutic options for patients with cardiovascular disease.
代谢物反映了细胞内稳态背后的动态过程。分析化学和分子生物学的最新进展为代谢物分析铺平了道路,有助于我们理解复杂的分子过程和生理学。代谢组学是对代谢物通量及其与生物表型关系的比较分析。作为中间表型,代谢物特征捕捉到了细胞动力学的一个独特方面,而这个方面通常不会被探究,为细胞内稳态提供了一个独特的视角。迄今为止,只有少数几项代谢组学研究调查了心血管疾病。在这篇综述中,我们探讨了代谢组学的原理,以及它如何为心血管生理学的机制提供更深入的见解,并最终为心血管疾病患者带来更好的诊断和治疗选择。