Guma Monica, Tiziani Stefano, Firestein Gary S
Division of Rheumatology, Allergy and Immunology, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0656, USA.
Department of Nutritional Sciences, University of Texas at Austin, 1400 Barbara Jordan Boulevard, Austin, Texas 78723, USA.
Nat Rev Rheumatol. 2016 May;12(5):269-81. doi: 10.1038/nrrheum.2016.1. Epub 2016 Mar 3.
Metabolomics enables the profiling of large numbers of small molecules in cells, tissues and biological fluids. These molecules, which include amino acids, carbohydrates, lipids, nucleotides and their metabolites, can be detected quantitatively. Metabolomic methods, often focused on the information-rich analytical techniques of NMR spectroscopy and mass spectrometry, have potential for early diagnosis, monitoring therapy and defining disease pathogenesis in many therapeutic areas, including rheumatic diseases. By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanisms are being revealed and are shaping our understanding of cell biology, physiology and medicine. These pathways can potentially be targeted to diagnose and treat patients with immune-mediated diseases.
代谢组学能够对细胞、组织和生物体液中的大量小分子进行分析。这些分子包括氨基酸、碳水化合物、脂质、核苷酸及其代谢产物，可以进行定量检测。代谢组学方法通常侧重于核磁共振光谱和质谱等信息丰富的分析技术，在包括风湿性疾病在内的许多治疗领域，具有早期诊断、监测治疗和确定疾病发病机制的潜力。通过进行整体代谢物分析，也就是非靶向代谢组学，将细胞途径与生物学机制联系起来的新发现不断涌现，正在塑造我们对细胞生物学、生理学和医学的理解。这些途径有可能成为诊断和治疗免疫介导疾病患者的靶点。
