抗组胺药物在治疗人类免疫缺陷病毒（HIV）相关性丘疹性瘙痒性发疹方面优于局部类固醇。

Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.

机构信息

Ifakara Health Institute, Ifakara, Kilombero, Tanzania.

出版信息

Int J Dermatol. 2010 Jan;49(1):83-6. doi: 10.1111/j.1365-4632.2009.04279.x.

DOI:10.1111/j.1365-4632.2009.04279.x

PMID:20465620

Abstract

Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.

摘要

丘疹性瘙痒症（PPE）是热带国家常见的 HIV 合并症。由于持续的瘙痒和社会耻辱感，有效的治疗方法受到高度重视。在坦桑尼亚农村地区的 HIV 队列中，我们分析了针对可用治疗方法的反应，该队列中 PPE 的患病率为 12%。口服羟嗪能显著改善瘙痒（P < 0.0058）和临床评分（P < 0.032），比局部类固醇更有效。疾病活动度与 CD4+和 CD8+ T 细胞计数无关，与抗逆转录病毒药物无关。因此，口服抗组胺药是 PPE 的有效一线治疗方法。