Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy.
Nat Rev Microbiol. 2010 Jun;8(6):393-9. doi: 10.1038/nrmicro2366.
The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.
补体系统是人类先天免疫反应的重要组成部分。最近对金黄色葡萄球菌和脑膜炎奈瑟菌的研究揭示了这些细菌如何逃避补体介导的杀伤。此外，新的结构数据提供了有关补体系统介导的宿主防御的分子机制以及细菌蛋白如何干扰这一过程的详细见解。这些信息对于我们理解细菌发病机制至关重要，并可能有助于设计更好的疫苗。
