Boskhomdzhiev A P, Banartsev A P, Makhina T K, Myshkina V L, Ivanov E A, Bagrov D V, Filatova E V, Iordanskiĭ A L, Bonartseva G A
Biomed Khim. 2009 Nov-Dec;55(6):702-12.
The aim of this study was to evaluate and to compare of long-term kinetics curves of biodegradation of poly(3-hydroxybutyrate) (PHB), its copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and PHB/polylactic acid blend. The total weight loss and the change of average viscosity molecular weight were used as an index of biodegradation degree. The rate of biodegradation was analyzed in vitro in presence oflipase and in vivo when the films were implanted in animal tissues. The morphology of PHB films surface was studied by atomic force microscopy technique. It was shown that biodegradation of PHB is occurred by means of as polymer hydrolysis, and as its enzymatic biodegradation. The obtained data can be used for development of medical devices on the base of PHB.
本研究的目的是评估和比较聚（3-羟基丁酸酯）（PHB）、其共聚物聚（3-羟基丁酸酯-co-3-羟基戊酸酯）以及PHB/聚乳酸共混物的长期生物降解动力学曲线。将总重量损失和平均粘均分子量的变化用作生物降解程度的指标。在脂肪酶存在的情况下体外分析生物降解速率，在将薄膜植入动物组织时体内分析生物降解速率。通过原子力显微镜技术研究了PHB薄膜表面的形态。结果表明，PHB的生物降解是通过聚合物水解以及酶促生物降解发生的。所获得的数据可用于基于PHB开发医疗器械。
