新西兰黑鼠杂交中自身免疫与逆转录病毒表达的遗传学研究。II. 病毒包膜糖蛋白gp70
Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice. II. The viral envelope glycoprotein gp70.
作者信息
Datta S K, McConahey P J, Manny N, Theofilopoulos A N, Dixon F J, Schwartz R S
出版信息
J Exp Med. 1978 Mar 1;147(3):872-81. doi: 10.1084/jem.147.3.872.
Abstract
The retroviral envelope glycoprotein, gp70 was measured in the serum of New Zealand Black (NZB) and SWR mice and the progeny of their crosses. The serum gp70 values segregated to "NZB-like" and "SWR-like" levels in these mice. A complex mechanism determined the inheritance of NZB-like serum gp70 levels. We found that the factors determining the expression of this retroviral protein were independent of the genes (Nzv-1 and Nzv-2) that determined the expression of infectious xenotropic virus. Autoimmune disease, including immune deposit nephritis could be dissociated from the degree of expression of serum gp70. By contrast, presence of circulating immune complexes and anti-DNA antibody did correlate with the development of nephritis in these crosses. A significant correlation was found between high grade expression of serum gp70 and the presence of lymphomas in these mice.
摘要
在新西兰黑鼠（NZB）和SWR小鼠及其杂交后代的血清中检测了逆转录病毒包膜糖蛋白gp70。这些小鼠血清中的gp70值分为“NZB样”和“SWR样”水平。一种复杂的机制决定了NZB样血清gp70水平的遗传。我们发现，决定这种逆转录病毒蛋白表达的因素与决定传染性嗜异性病毒表达的基因（Nzv-1和Nzv-2）无关。包括免疫沉积性肾炎在内的自身免疫性疾病与血清gp70的表达程度无关。相比之下，循环免疫复合物和抗DNA抗体的存在与这些杂交后代中肾炎的发生相关。在这些小鼠中，血清gp70的高表达与淋巴瘤的存在之间存在显著相关性。
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