Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Vet Pathol. 2010 May;47(3):434-45. doi: 10.1177/0300985810363705.
Histiocytic sarcoma (HS) and histiocyte-associated lymphoma (HAL) of mice are difficult to distinguish histologically. Studies of multiple cases initially diagnosed as HS or HAL allowed us to define HS as round, fusiform, or mixed cell types that were F4/80+, Mac-2+, and PAX5-; that lacked markers for other sarcomas; and that had immune receptor genes in germline configuration. Two other subsets had clonal populations of lymphocytes. The first, HAL, featured malignant lymphocytes admixed with large populations of normal-appearing histiocytes. The second appeared to be composites of lymphoma and HS. Several cases suggestive of B myeloid-lineage plasticity were also observed.
组织细胞肉瘤（HS）和与组织细胞相关的淋巴瘤（HAL）在组织学上难以区分。对最初诊断为 HS 或 HAL 的多个病例的研究使我们能够将 HS 定义为圆形、梭形或混合细胞类型，这些细胞类型为 F4/80+、Mac-2+和 PAX5-；缺乏其他肉瘤的标志物；并且具有免疫受体基因的种系构型。另外两个亚组具有克隆性淋巴细胞群体。第一个是 HAL，其特征是恶性淋巴细胞与大量外观正常的组织细胞混合。第二个似乎是淋巴瘤和 HS 的组合。还观察到几个提示 B 髓样系可塑性的病例。
