Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China.
J Pharmacol Sci. 2010;113(1):23-31. doi: 10.1254/jphs.09231fp.
Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2alpha1 mRNA expression at all time points; and decreased Col10alpha1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1beta mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.
腰椎退变在大多数慢性下腰痛中起着重要作用。因此，预防腰椎间盘（IVD）退变是一个高度优先的研究课题。我们之前的多中心临床试验和药理学研究都表明，一种新获得专利的中药复方七芍巴布剂（FFQSP）可以有效缓解颈痛症状并预防颈椎退变。为了阐明 FFQSP 对腰椎 IVD 退变的影响，我们应用了一种由长时间直立姿势引起的腰椎 IVD 退变大鼠模型。FFQSP 预处理一个月可预防组织学变化，表明 IVD 结构紊乱；增加 II 型胶原水平，降低 X 型胶原蛋白水平，并在所有时间点增加 Col2alpha1 mRNA 表达；并降低 Col10alpha1、基质金属蛋白酶（MMP）-3、MMP13 和白细胞介素（IL）-1βmRNA 表达，直立姿势 7 和 9 个月。这些结果表明，FFQSP 可预防由直立姿势引起的腰椎 IVD 退变。FFQSP 是治疗腰椎 IVD 退变疾病的一种有前途的药物。
