维拉帕米对胃溃疡的保护作用。
Protection against gastric ulcer by verapamil.
作者信息
Srivastava S K, Nath C, Gupta M B, Vrat S, Sinha J N, Dhawan K N, Gupta G P
机构信息
Department of Pharmacology, (C.D.R.I.), King George's Medical College, Lucknow, India.
出版信息
Pharmacol Res. 1991 Jan;23(1):81-6. doi: 10.1016/s1043-6618(05)80109-4.
PMID:2047362
Abstract
The effect of verapamil, a calcium channel blocker, was studied against stress (cold restraint), aspirin and pylorus ligation induced gastric ulcers in rats. Verapamil inhibited ulcerogenic response and ulcer index in all the three types of ulcers. Verapamil also decreased total and free gastric acidity without changing gastric secretory volume.
摘要
研究了钙通道阻滞剂维拉帕米对大鼠应激（冷束缚）、阿司匹林和幽门结扎诱导的胃溃疡的作用。维拉帕米抑制了所有三种类型溃疡的致溃疡反应和溃疡指数。维拉帕米还降低了总胃酸和游离胃酸，而不改变胃分泌量。
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