Kalra Pankaj, Sharma Sunil, Kumar Suresh
Rayat and Bahra Institute of Pharmacy, Mohali, Chandigarh.
J Pharm Bioallied Sci. 2011 Apr;3(2):236-41. doi: 10.4103/0975-7406.80778.
Peptic ulcer is a global health problem of the gastrointestinal tract characterized by mucosal damage secondary to pepsin and gastric acid secretion which occurs due to due to an imbalance between offensive and defensive factors.
The present study was carried out with methanolic extract of the seed coat of Tamarindus indica Linn. to evaluate its antiulcer potential on ibuprofen, alcohol and pyloric ligation induced gastric lesions.
Doses of 100 mg/kg & 200 mg/kg of methanolic extract wre administered orally to rats of different groups. Ranitidine at a dose of 50 mg/kg was used as a standard drug for these gastric ulcer models. The gastric content was collected and the volume was measured. The ulceration index was determined by examining the inner lining of each stomach. Furthermore, the effect was assessed by free acidity, pepsin activity, total carbohydrate (TC), protein content (PK).
The result showed that the methanolic extract of seed coats of Tamarindus indica significantly reduce the total volume of gastric juice, free and total acidity of gastric secretion (P < 0.01) in pylorus ligation induced ulcer model as is comparable with the standard drug ranitidine. There was also a significant reduction in ulcer index (P < 0.01) as compared to control group.
The methanolic extracts of seed coat of Tamarindus indica can be used as a new source of antiulcer agent in animals.
消化性溃疡是一种全球性的胃肠道健康问题，其特征是由于攻击因子和防御因子失衡导致胃蛋白酶和胃酸分泌引起的黏膜损伤。
本研究采用罗望子种皮的甲醇提取物，评估其对布洛芬、酒精和幽门结扎诱导的胃损伤的抗溃疡潜力。
将不同剂量（100mg/kg和200mg/kg）的甲醇提取物口服给予不同组的大鼠。以50mg/kg的雷尼替丁作为这些胃溃疡模型的标准药物。收集胃内容物并测量其体积。通过检查每个胃的内壁来确定溃疡指数。此外，通过游离酸度、胃蛋白酶活性、总碳水化合物（TC）、蛋白质含量（PK）来评估效果。
结果表明，罗望子种皮的甲醇提取物在幽门结扎诱导的溃疡模型中显著降低了胃液的总体积、胃酸分泌的游离酸度和总酸度（P<0.01），与标准药物雷尼替丁相当。与对照组相比，溃疡指数也显著降低（P<0.01）。
罗望子种皮的甲醇提取物可作为动物抗溃疡剂的新来源。
